Paul Coleman on Biochemical assay for AD7C-NTP in urine as an Alzheimer's disease marker.

COMMENT It is not clear from the abstract how much overlap there may be between AD and controls. Neither is it clear how well this test may distinguish AD from other dementing diseases. Paul_Coleman 0 ...

Benjamin Wolozin on The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner.

COMMENT Recent findings suggest that APP stimulates gene transcription. This study provides important confirmation for that observation. bwolozin 0 ...

Nikolaos K. Robakis on Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.

COMMENT This is a very interesting report. As suggested by the authors, it could lead to the discovery of pharmacological agents that decrease amyloid production by acting on LRP. nikos.robakis 0 ...

Hiroshi Mori on Human blood-brain barrier receptors for Alzheimer's amyloid-beta 1- 40. Asymmetrical binding, endocytosis, and transcytosis at the apical side of brain microvascular endothelial cell monolayer.

COMMENT This is an important paper showing the biochemical study on Abeta1-40 species in vascular deposition as non-plaque components. mori 0 ...

Hiroshi Mori on Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body disease.

COMMENT We need multiple information on synuclein for Lewy body disease etiology. It is informative to know the time required for formation of mature fibrils. mori 0 ...

Elliott Mufson on No association between apolipoprotein E epsilon 4 allele and rate of decline in Alzheimer's disease.

COMMENT Interesting. emufson 0 ...

John Olney on High affinity glutamate transporters: regulation of expression and activity.

COMMENT These authors provide a competent review of new findings in the glutamate transporter field, a field which ultimately may provide insights into neurodegenerative diseases. At present they are just beginning to develop the probes necessary to evaluate the ...

Benjamin Wolozin on Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

COMMENT This paper provides further support for the observation that use of statins is associated with a lower risk of AD. Specifically, this paper reduces the possibility that the negative correlation between statin use and AD is due to the a spurious outcome of ...

John Hardy on Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease.

COMMENT The difficulty we have had proving a role for the polymorphisms in the APOE promoter in AD (and the general consensus seems to be that they have a role), illustrates the difficulty we will have in determining whether genetic variability at other non ...

Hiroshi Mori on Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells.

COMMENT As the authors suggest here, amyloid angiopathy may come from outside the brain, in blood flow. But, it is still questionable whether wild amyloid peptide comes from the same origin as Dutch-type one. mori 0 ...

Paul Coleman on Phosphorylated tau can promote tubulin assembly.

COMMENT The abstract states 'PKA-phosphorylated tau (2.7 mol phosphates/mol) does not promote tubulin assembly as judged by spectrophotometric and atomic force microscopy measurements, unless trimethylamine N-oxide (TMAO), a natural occurring osmolyte, is ...

Hiroshi Mori on Human amyloid precursor-like protein 1--cDNA cloning, ectopic expression in COS-7 cells and identification of soluble forms in the cerebrospinal fluid.

COMMENT Any papers are interesting and important as far as they include the primary sequence of the molecule but this paper for human APLP1 is particularly interesting because its distribution was quite similar to that of APP. mori 0 ...

Nikolaos K. Robakis on alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies.

COMMENT Elucidation of the abnormal protein aggregations found in Lewy bodies is important as this disease is very much related to AD. nikos.robakis 0 ...

Hiroshi Mori on Apolipoprotein E polymorphism in patients with Alzheimer's disease, vascular dementia and ischemic cerebrovascular disease.

COMMENT The result says that ApoE epsilon 4 allele influences VD, ICVD as well as AD. This indicates ApoE is a risk factor for amyloid deposition rather than AD specifically. mori 0 ...

Carl Cotman on Direct conversion of an oligopeptide from a beta-sheet to an alpha-helix: a model for amyloid formation.

COMMENT Reversibility is northy. cwcotman 0 ...