8835 RESULTS
COMMENT Reply by Steven Barger Regardless of whether presenilins really are γ-secretases (for which the data seem to tipping the scales), the data seem quite clear that they are somehow involved in proteolytic processing of both APP and Notch. To me, one of the ...
COMMENT Reply by E. Preddie and J. Bergmann 1. Considering what was known before, the nature of the experiments done by Wolfe and colleagues and the results obtained, it appears that the conclusion expressed by 'Ye' et al from their results is equally ...
COMMENT Reply to Ratan Bhat by Rudy Tanzi: The main problem with this hypothesis is that since the time of publication of the commentary by Tuck Finch and I in Science, we now know that PS2 does not bind β- or delta-catenin (Tesco et al., J. Biol Chem., 1998). ...
COMMENT Question from Ratan Bhat There have been suggestions that an increase in beta-catenin could mask some the mutation sites within PS1 (Tanzi and Finch in their Science comment), thereby stabilizing PS1, decreasing γ-secretase activity and subsequently β ...
COMMENT Reply by Dennis Selkoe Dear John: In response to your News and Views in the 8 April issue of Nature, I thought it would be helpful to indicate several points about your comments regarding the role of presenilins in APP processing with which my colleagues ...
COMMENT As a quick comment regarding Luc Buee's summary of Dr. Lindsay Farrer's talk on the genetics of AD and chromosome 12 in the Genetics I session of the Sixth Int. Conference on AD in Amsterdam, Dr. Buee reports that Dr. Farrer's genetic ...
COMMENT Dr. Lukiw does not mention that Dr. Peggy Vance reported that she replicated our significant genetic association of A2M and AD using the same A2M polymorphism (exon 18 deletion) in the same AD families (NIMH AD family set N = ~350) that we used and with ...
COMMENT Dear Dr. Kosik, It was an honor that our work, presented at the Sixth International Conference on AD, was described in your briefing about presenilin-binding proteins. Similarly to your team and the identification of the catenins as possible modulators of ...
COMMENT This necessary study supports, once again, the idea that microglia do not affect plaque formation in mouse models unless they are "activated" by drugs or immunotherapy or replaced by fresh macrophages. Whether this applies to humans, too, ...
COMMENT A very interesting finding, indeed! saak.ovsepian 0 ...
COMMENT This study is most interesting. It gives strong evidence that manipulation of the innate immune system is an important therapeutic target for AD. The authors have shown that stimulation of innate immunity via TLR9 leads to reduction in both Aβ and tau ...
COMMENT This is a very interesting concept. Almost three decades ago, we postulated the same hypothesis, based on histologic analysis of aged brains, demonstrating a blood brain barrier (BBB) breakdown and leakage of serum proteins in aged (but not young) human ...
COMMENT High-resolution structures of γ-secretase have revealed the architecture of one of the most intriguing proteases. Moreover, co-structures with the allosteric inhibitor DAPT and a short co-purifying peptide uncovered the pocket and interaction mode for ...
COMMENT This is an interesting paper. I am looking forward to seeing more mechanistic characterization in the future, in particular using primary neurons and endogenous APP, but also regarding the mechanistic basis of the differential effect on different BACE ...
COMMENT This report by Jagust and colleagues represents an interesting and valuable contribution to the literature on SNAP. They demonstrate that there is little difference when using either hippocampal volume or FDG-PET for classifying neurodegeneration. In line ...
