Nikolaos K. Robakis on Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

COMMENT It is important to clarify the issue of PS1 involvement in apotosis, especially since many people in the field work under the assumption that PS apotosis is involved in AD. The data in this paper is not consistent with the theory that PS apotosis is ...

Elliott Mufson on Aging and Alzheimer's disease: lessons from the Nun Study.

COMMENT Noteworthy emufson 0 ...

Benjamin Wolozin on Identification of genes that modify ataxin-1-induced neurodegeneration.

COMMENT This is a gorgeous paper that offers fundamental insights into the mechanism of disease processes. bwolozin 0 ...

Elliott Mufson on Acetylcholine, aging, and Alzheimer's disease.

COMMENT Useful review. emufson 0 ...

John Olney on Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions.

COMMENT The article by Hollister et al provides useful information regarding the potential role of kinase enzymes in NFT formation in that it studies 4 different kinases and shows that only one of them has the proper messenger RNA distribution to make it a ...

Edward Koo on Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease.

COMMENT Interesting approach. But the dating can be mislead by more turnover of plaques than tangles. edkoo 0 ...

Hiroshi Mori on Complete genomic screen in late-onset familial Alzheimer's disease.

COMMENT A new locus to explain the great majority of sporadic Alzheimer's disease is examined here. Although it is not yet identified, their trial is shown here in detail which should be respected and be expected. mori 0 ...

Paul Coleman on Brain volume preserved in healthy elderly through the eleventh decade.

COMMENT Another study for the older folks. Paul_Coleman 0 ...

Paul Coleman on Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

COMMENT Would this represent an improvement over other cholinergic agents currently in the pipe;ine for treatment of AD? Is there any expectation that SA4503 would have an effect on the basic mechanism of AD pathology? Paul_Coleman 0 ...

Elliott Mufson on The mean A beta load in the hippocampus correlates with duration and severity of dementia in subgroups of Alzheimer disease.

COMMENT Interesting study. emufson 0 ...

Benjamin Wolozin on Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented.

COMMENT Predictive test? Could be important. bwolozin 0 ...

Nikolaos K. Robakis on The Drosophila beta-amyloid precursor protein homolog promotes synapse differentiation at the neuromuscular junction.

COMMENT This is an important finding as it suggests that APP may also have a role in synaptic structure or function. We should remember that AD is probably a synaptic disorder. nikos.robakis 0 ...

John Olney on Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease.

COMMENT Kimpara et al report finding a polymorphic feature of a promoter region of the human HO-1 gene and suggest that this may be a useful marker for studying certain human diseases. However, they apparently do not find evidence for particular alleles ...

Elliott Mufson on ApoE genotype does not affect plasma tPA and PAI-1 antigen levels.

COMMENT Interesting special issue (also see articles below). emufson 0 ...

Paul Coleman on Alzheimer neuropathologic alterations in aged cognitively normal subjects.

COMMENT 'Our study demonstrates that the brains of a large percentage of cognitively normal, relatively well-educated individuals contain numerous degenerative changes and only a small percentage are relatively free of these changes.' The changes ...