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Agata Copani on Adult Neurogenesis—A Win Wnt Situation?

COMMENT The canonical Wnt signaling pathway has multiple roles in stem/progenitor cells. In embryonic stem cells, activation of Wnt promotes self-renewal and inhibits neural differentiation (1,2). In the central nervous system, Wnt3a is required for neural progen

Paul Coleman on Looking outside the Brain for Early Signs of AD

COMMENT Rather than focus on details, I would like to emphasize the main point that the authors have analyzed the relative expression levels of a large number of genes using a (necessarily) small number of cases. The authors correctly saw the need for validation,

Mary Reid on Escort Service: P-Glycoprotein Ushers Aβ from Brain

COMMENT This study by the Holtzman lab is most interesting. I had proposed that inhibition of P-glycoprotein together with Gleevec may be a useful therapy in AD. The study I'd referenced in my poster found that levels of Gleevec in the brain were higher in m

Nibaldo Inestrosa on Adult Neurogenesis—A Win Wnt Situation?

COMMENT The identification of Wnt signaling as a major player in the regulation of adult hippocampal neurogenesis is probably one of the most important scientific discoveries of this year. Gage´s lab not only opens an exciting new avenue for the understanding of

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