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Tobias Hartmann on AβPP Processing—Limping Along on Lipases

COMMENT Aβ generation strongly depends on lipids. First of all, APP is a membrane protein, defining its most proximate neighboring molecules; second, substrate turnover of the secretases is regulated by membrane lipid composition; and third, Aβ peptides are signa

Markus Glatzel on Prion Protein: A Force for Good in Stem Cells

COMMENT Zhang et al. show that the physiological form of the prion protein, PrPC, is expressed on hematopoietic stem cells, and may play a role in hematopoietic stem cell renewal. The authors speculate that PrPC might be a (co)receptor, protecting hematopoietic s

Andrea LeBlanc on Prion Protein: A Force for Good in Stem Cells

COMMENT This is the first time that the prion protein has been shown to be implicated in hematopoietic stem cell survival or proliferation. Such a role for prion protein is unexpected since most prion protein mutations affect the nervous system and not the periph

Eef Hogervorst on Not Dead Yet: Estrogen Deserves Another Chance

COMMENT On the basis of our own clinical trial, and the literature reviews and meta-analyses that we have carried out, I think that estrogens, both estradiol and conjugated equine estrogens, may improve cognition, but only for a limited period of 2-3 months, afte

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