140 RESULTS
COMMENT Kumar and colleagues set out in their study to characterize a variety of available ‘conformation- specific antibodies’ for α-Syn to test the antibodies’ specificity toward monomeric, oligomeric and fibrillar forms of α-Syn. The results largely agree with ...
COMMENT In this important study, Kumar and colleagues conducted an impressive amount of rigorous work on the study of different forms and assemblies of alpha-synuclein, a central protein in synucleinopathies. The study is systematic, carefully executed, and ...
COMMENT I think most thoughtful people in the field have wished for better antibodies for some time. This work will make it clear how urgent that is. The question is whether it’s possible to get them. Structural biologists have often been suspicious of ...
COMMENT This is an extremely useful analysis of the current α-Syn antibodies used in the field, and quite an ‘eye-opener’. The study clearly shows that all the antibodies that have claimed to be ‘oligomer/conformation-specific’ also detect fibrils, i.e. the ...
COMMENT Downstream of dysfunctional astrocytes in AD, one process that loss of glutamate homeostasis may converge on is excitotoxic neuronal and synapse loss. Deficits in glutamate uptake capacity due to glutamate transporter hypo-expression, bioenergetic ...
COMMENT Epidemiologists have known for more than a decade that blood-pressure-lowering medicines, such as ACE inhibitors and angiotensin receptor blockers, are associated with reduced incidence and prevalence of Alzheimer’s disease. The recent discovery of an SNP ...
COMMENT Thrupp et al. compared single-nucleus (snRNA-Seq) and single-cell RNA-seq (scRNA-Seq) datasets generated from the temporal lobes of four human donors, and argue that the identification of microglial activation states—which are clearly implicated in AD ...
COMMENT This study shows that a small population of genes implicated in microglial activation, such as APOE, CST3, SPP1, and CD74, is depleted in “nuclei” versus “whole cell” single-cell RNA sequencing technologies. Importantly, these genes are part of the ...
COMMENT Thrupp et al. propose that snRNA-Seq technology fails to recapitulate microglia activation states in humans because activation genes are underrepresented in non-diseased human brains by snRNA-Seq. The paper reveals a difference in sensitivity between ...
COMMENT This is a fascinating and elegant study, opening up a new potential therapeutic pathway to treat neurologic diseases that manifest extrasynaptic NMDAR hyperactivity—including AD. The Bading approach allows us to potentially intervene at a downstream event ...
COMMENT Although the biogenesis of Aβ in familial AD is well-documented, Aβ production in sporadic AD is not well understood. We identified circAβ-a and analyzed its formation in prefrontal cortex samples of sporadic AD patients, non-dementia controls, and ...
COMMENT Asher and colleagues present the conclusions from a working group convened by the National Institute on Aging to evaluate the potential risk of handling proteopathic seeds associated with neurodegenerative diseases. They provide a concise and informative ...
COMMENT In this exciting work, Darwich et al. characterize an autosomal-dominant D395G mutation in the AAA+ ATPase chaperone VCP, which is associated with "vacuolar tauopathy" (VT), a novel form of tauopathy. Dr. Edward Lee's group provides ...
COMMENT Development of an unprecedented nonhuman primate model (NHP) of familial Alzheimer’s disease (FAD) by Saido and colleagues is an outstanding accomplishment. As others mentioned on Alzforum, a familial NHP model is a significant contribution to the AD ...
COMMENT We commend the careful wording in the new paper by Steve Collins and colleagues that reports a significant increase in intracerebral hemorrhage (potentially related to amyloid-β cerebral amyloid angiopathy (CAA)) in a group of c-hGH recipients, but no ...
