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Diane Stephenson on RIP: Serotonin Receptor 5-HT6 Antagonist

COMMENT Thank you for posting this important feature, Alzforum colleagues.  I was one of many drug hunters 10 to 20 years ago, chasing lead molecules as selective and potent as we could find, and testing these leads in animal models to demonstrate their effect on ...

Hugo Geerts on RIP: Serotonin Receptor 5-HT6 Antagonist

COMMENT Despite these setbacks, I would disagree that the 5-HT6 antagonist concept is dead. Although we don’t have the details, it is likely that the clinical trial design did not take into account the pharmacodynamic (PD) interactions of 5-HT6 antagonists with ...

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