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Mathias Jucker on Are Microglia Plaque Factories?

COMMENT This nice study by Green’s group investigates what happens after elimination of microglia in the 5xFAD mouse model. The hypothesis they propose, i.e., that microglia take up Aβ and form fibrils, is interesting but not novel. Wisniewski and others came to ...

John Breitner on In Alzheimer’s, More TREM2 Is Good for You

COMMENT These findings fit quite elegantly with our recent findings and hypothesis that innate immune activity modulates development of presymptomatic AD, and that markers of immune activation are generally beneficial (Meyer et al., 2019). For various reasons we ...

David Hansen on In Alzheimer’s, More TREM2 Is Good for You

COMMENT The findings of Ewers et al. provide a valuable advance for understanding how measurements of the biomarker CSF sTREM2 relate to the rate of disease progression around the early symptomatic stages of Alzheimer’s. What the data imply, as far as TREM2 and ...

Gary Landreth on In Alzheimer’s, More TREM2 Is Good for You

COMMENT The roles of TREM2 in AD pathogenesis have commanded substantial attention following from the recognition that TREM2 variants are associated with dramatically elevated AD risk. Previous work from this group reported that soluble forms of TREM2 were found ...

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