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Wiep Scheper on Does Tau Kill Neurons by Way of Necroptosis?

COMMENT This extensive and well-performed study by Koper et al. shows an interesting novel feature of GVBs, as their core is immunopositive for necrosomes. As the authors and commentators indicate, caution is warranted with mechanistic interpretation based on ...

Veronique Miron on Does Tau Kill Neurons by Way of Necroptosis?

COMMENT This study raises three major questions: Do neurons undergo a delayed slow necroptosis in AD? If so, how do microglia respond? And do microglia undergo necroptosis in AD? The authors demonstrate co-localization of activated necrosome components within ...

Shijun Zhang on Does Tau Kill Neurons by Way of Necroptosis?

COMMENT This was a very nice study of AD patients and control brain samples, showing the presence of pRIPK1, pRIPK3, and pMLKL in granulovacuolar degeneration (GVD) of neuronal cells. The analyses are solid and convincing. Although differences exist with regard ...

Steven Finkbeiner on Does Tau Kill Neurons by Way of Necroptosis?

COMMENT I think the demonstration of necrosomes’ positive granulovacuolar degeneration (GVDn+) in AD brains is interesting and new, and opens up new lines of research and potentially new therapeutic targets. However, I think the mechanistic relationship between ...

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