8719 RESULTS
COMMENT Among the now several “-omics” papers on Alzheimer’s disease that have emerged in the last few years, this new report by Zhou et al. stands out because of its comprehensive analysis of mouse and human tissue at the single-cell level. One of the more ...
COMMENT This study from Yingyue Zhou from the Colonna lab is exactly the sort of study that the field should be doing more of—comparing actual human transcriptomic analyses with those from animal models is the key to determining which cell types (or subtypes of ...
COMMENT This extensive and well-performed study by Koper et al. shows an interesting novel feature of GVBs, as their core is immunopositive for necrosomes. As the authors and commentators indicate, caution is warranted with mechanistic interpretation based on ...
COMMENT Overall I think this is a beautiful study. It makes a clear point that immune components are essential for our understanding of Alzheimer’s disease. Whether these are causal factors or part of the repair mechanism, or a repair system that went wrong, it ...
COMMENT This study raises three major questions: Do neurons undergo a delayed slow necroptosis in AD? If so, how do microglia respond? And do microglia undergo necroptosis in AD? The authors demonstrate co-localization of activated necrosome components within ...
COMMENT This was a very nice study of AD patients and control brain samples, showing the presence of pRIPK1, pRIPK3, and pMLKL in granulovacuolar degeneration (GVD) of neuronal cells. The analyses are solid and convincing. Although differences exist with regard ...
COMMENT I think the demonstration of necrosomes’ positive granulovacuolar degeneration (GVDn+) in AD brains is interesting and new, and opens up new lines of research and potentially new therapeutic targets. However, I think the mechanistic relationship between ...
COMMENT This article by Gate et al. elegantly shows the presence of clonally expanded CD8 T cells in Alzheimer’s disease. The primary question regarding the finding is the degree to which these cells are secondary to the disease process or actually play a ...
COMMENT We and others have been exploring the role of T cells in cognition and in neurodegenerative diseases and aging and this beautiful study shows, for the first time, a close association among T cells, cognition, and AD in humans. These elegant findings on ...
COMMENT "Tau factor" was initially described by Marc Kirschner and colleagues as a protein promoting the assembly of microtubules (MT) in neurons (Weingarten et al., 1975). Within the same year Joe Bryan and colleagues showed that tau also interacts ...
COMMENT Great review article, thank you for writing. A few clarifying points: 1) The therapeutic goal of harnessing microglia to treat AD through activating Trem2 or inhibiting CD33 goes far beyond "spur microglia to clear amyloid." Microglia have a ...
COMMENT This article describes an interesting concept, where microglial microRNAs contribute to tau pathology (in neurons) in a sex-specific manner. Sex differences in onset and progression in Alzheimer’s disease and related tauopathy have been previously ...
COMMENT The expanded research on LSDs is exciting and has great potential to inform therapeutic approaches for Alzheimer’s disease (AD) and aging-related neurodegenerative diseases. Urgency and accumulated evidence also justify accelerated efforts now toward ...
COMMENT This paper presents an important strategy for conformationally selective targeting of misfolded proteins in vivo. The authors show in a Tg2576 mouse model that impairment of SVZ adult neurogenesis is an early event in the progression of neurodegeneration. ...
COMMENT It is easy to forget in the excitement around the amyloid studies that clinical trial results with alternative approaches have been presented, some with impressive results. In particular, the small NA-831 (traneurocin) Phase 2 trial showed an impressive ...
