8901 RESULTS
COMMENT Thank you for your comment, Pete. Hopefully we as a field will learn a lot more about LATE in the coming years and get closer to identifying potential therapeutic targets. To answer your question, neither ABCC9 nor KCNMB2 variant showed a significant (p ...
COMMENT This paper provides an exciting and important step forward in the understanding of the multiple functions of the PLCγ2 enzyme in microglia. Although previous studies have described a key role for this PLC isoform in the regulation of peripheral immune ...
COMMENT This study eloquently consolidates Magno et al., 2019, and Maguire et al., 2020, and it adds to our understanding of the interaction of TREM2 and PLCγ2 as well as the independent role of PLCγ2 in iMG. The authors present a clear hypothesis as to how these ...
COMMENT The authors developed methods to generate a BBB-like structure by putting together brain endothelial cells (BEC), mural cells (iMC), and astrocytes differentiated from human iPSCs. Because each of the BBB components can be derived individually, the ...
COMMENT This is a very elegant study, both technically in establishing a model of blood-brain barrier from induced brain endothelial, astrocyte, and pericyte-like cells, and then applying it to study the effects of ApoE4 on amyloid deposition and calcineurin-NFAT ...
COMMENT Joel Blanchard and Li-Huei Tsai have developed an interesting in vitro BBB model made of human induced pluripotent stem cells (iPSCs) differentiated into endothelial cells, pericytes, and astrocytes, that they named iBBB. First, they found that iPSC ...
COMMENT The Tsai lab provides some remarkable insight into the generation of cerebral amyloid angiopathy, which may identify potential therapeutics for Alzheimer's disease. A large percentage of people with AD develop amyloid plaques along their blood ...
COMMENT TMEM106B has a strong association with brain pathology and was discovered as a risk allele in diseases on the ALS/FTLD spectrum. But indeed, the main impact of TDP-43 proteinopathy on public health is on LATE, which is >100-fold more common than ALS ...
COMMENT This is a very interesting study. It linked TREM2 and PLCG2 signaling pathways in IPSC-derived macrophages/microglial cells to get insights into the mechanisms underlying the deleterious effect of TREM mutations and the protective effect of the PLCG2 ...
COMMENT Andreone and colleagues have provided an extensive and compelling study on the roles of the PLCγ2 in human iPSC-derived microglia-like cells. A significant outcome of this study is the validation that the findings in the human iMG cells largely ...
COMMENT This study provides important new insights into the cell biological functions of PLCγ2 in (human) microglia. It has been known for some years that a coding variant in PLCγ2 (P522R) protects from Alzheimer’s disease and other dementias, but how PLCγ2 (a ...
COMMENT This is a very important paper, because it supports the idea to therapeutically modulate TREM2 functions in microglia. Andreone and colleagues independently support this approach by demonstrating shared LOF phenotypes upon TREM2 or PLCγ2 knockout. This ...
COMMENT This exciting new study by Andreone et al. examines the importance of PLCy2 activity downstream of TREM2 signaling for survival, myelin phagocytosis, lipid metabolism, and processing of neuronal debris by human microglia. This work also provides an ...
COMMENT This is a very nice paper. It establishes that liquid-like states of α-synuclein promote the assembly of amyloid-like aggregates and that there are various physical chemical factors such as pH and metal ions that shift the equilibrium toward liquid ...
COMMENT Ever since the origin of Aβ was shown to be the result of proteolytic processing of the juxta-membranous and intramembranous domains of a beta-amyloid precursor protein (APP) (Kang et al., 1987), it has been apparent that this phenomenon must reflect some ...
