9237 RESULTS
COMMENT We thank our colleagues for noting the statistical power of focusing on paradoxical APOE2/4 genotype-phenotypes to find potential AD genes, the deeper resolution provided by a variant impact weighting method, and the added confidence provided by in vivo ...
COMMENT This study tackles one of the biggest challenges in treating people living with multiple sclerosis (MS), which is our limited ability to slow disability accumulation in progressive MS. Despite an immense effort, treatment options for progressive MS are ...
COMMENT Schnier et al. present a new, impressive epidemiological analysis in four large European cohorts to investigate a potential association of herpesvirus infection with the later development of dementia. Results from this study are, as previous ones, ...
COMMENT This study strings together a series of enlightening and novel observations regarding cortical synapse decline in a model of cortical multiple sclerosis (c-MS), and aligns excitatory synapse loss, increased calcium load in dendrites and spines, phagocyte ...
COMMENT To date, I’m not convinced by any of the experimental or clinical evidence that a conventional virus underlies the pathogenesis of AD. Latent or temperate conventional viral activity may, however, play a role in the relatively common phenocopy of AD, ...
COMMENT Bocharova et al. tested 5XFAD mice in an attempt to replicate our results demonstrating a protective role of Aβ against HSV1 (Eimer et al., 2018). Bocharova et al. present data intended to suggest the contrary; however, we do not believe their data ...
COMMENT Bocharova et al. present an interesting perspective on the role of Aβ as an antimicrobial peptide. Rob Moir and colleagues had reported earlier that Aβ has antimicrobial activity in vitro against bacteria and yeast (Soscia et al., 2010), agglutinates ...
COMMENT This interesting work raises questions such as how does the immune system surveil the CNS? One answer comes from a new paper in Cell led by Jonathan Kipnis, which shows immune cells in the meninge. When they study an MS mouse model, they find activated ...
COMMENT This elegant genetic study may have identified several important genes that may protect APOEε4-carriers from, or reduce APOEε2 carriers’ protection against, Alzheimer's disease. Both findings challenge our current understanding of APOE genotype as a ...
COMMENT Many thanks to Chelsea Weidman Burke for a great summary of our research and to you, colleagues, for excellent comments. One of the first things Chelsea asked us was to comment on the heterogeneity of results between the four cohorts, and our response was ...
COMMENT These findings are quite consistent with reports, espoused by many eminent researchers, and central to our stance on www.ALZgerm.org, that many viruses, bacteria, and parasites can enter the brain, either temporarily or long-term. They may live quietly, ...
COMMENT Our findings show that the SARS-CoV-2 viral spike protein S1, which is required for cellular uptake of virus, can enter the mouse brain following intravenous or intranasal administration. This might relate to the fact that people with COVID-19 are often ...
COMMENT This fascinating study by Wang et al. further expands the already numerous roles of Apolipoprotein E (APOE) in health and disease to now include the world’s major public health challenge, COVID-19. The authors employ a variety of human iPSC lines and ...
COMMENT This is an interesting and timely work using hiPSC-derived neural models to understand the potential implications of SARS-CoV-2 infection in the brain. While neurological symptoms have been attributed to infection, the mechanisms behind these symptoms are ...
COMMENT ApoE isoform-dependent SARS-CoV-2 neurotropism and cellular response The paper by Wang, Zhang, and colleagues suggests that ApoE4/4 neurons and astrocytes are more readily infected by SARS-CoV2 than ApoE3/3 neurons. This finding is interesting but the ...
