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Yannick Vermeiren on Tiny Brain Structure Plays Big Role in Memory

COMMENT The work of Dahl and colleagues confirms the supposition that the locus coeruleus may be spatially organized in rostral and caudal segments, each projecting to particular target regions that exert various neurobehavioral functions, among them being memory ...

Scott Counts on Tiny Brain Structure Plays Big Role in Memory

COMMENT Our group and others have shown that postmortem variables such as locus coeruleus neuron number, density, and volume are all associated with antemortem performance in multiple cognitive domains, including memory. If you think about the role of forebrain ...

Benjamin Wolozin on Islands of Tau Coat and Protect Cytoskeleton

COMMENT These papers by Siahaan et al. and Tan et al. add to a growing body of work emphasizing the importance of phase separation in biology, and the specific importance of this work in tau biology. Previous work by the Hyman laboratory demonstrated the ...

Kenneth Kosik on Islands of Tau Coat and Protect Cytoskeleton

COMMENT Phase states of tau can regulate microtubule function These new tau papers advance our knowledge of tau protein function at a mechanistic level. Previous work showed that tau is an RNA-binding protein capable of undergoing liquid-liquid phase separation ...

Jürgen Götz on Islands of Tau Coat and Protect Cytoskeleton

COMMENT Both studies elegantly identify novel interactions between tau and microtubules (MTs) in a physiological setting, either in regulating tau condensation or in protecting MTs from depolymerizing. I have been reminded of a paper from the Safinya lab on the ...

Marco Colonna, Simone Brioschi on Are Microglia Plaque Factories?

COMMENT This latest work from Kim Green’s laboratory shows that prolonged microglia depletion in 5xFAD mice (a common mouse model for AD) greatly reduces plaque formation, thus confirming recent findings by another group (Sosna et al., 2018). Notably, this ...

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