Shirley ShiDu Yan on Hot in Here? Or Is it Just My Mitochondria?

COMMENT This is an interesting observation and the thermos-sensitive fluorescent probe may become a tool for observing mitochondrial function. Based on the results generated from in vitro human cell lines, it appears that mitochondrial respiratory function ...

Sid O'Bryant on Closing in on a Blood Test for Alzheimer’s?

COMMENT This is very interesting and promising discovery work. The authors provided an initial replication study in AIBL, which further supports this very early work. Much remains to be done, but I am excited by these findings and leveraging both of these studies ...

Kaj Blennow on Closing in on a Blood Test for Alzheimer’s?

COMMENT These results are very promising, and lend further support to the use of blood Aβ as a screening biomarker for brain amyloidosis. The results add to the recent paper published last year that also used immunoprecipitation and mass spectrometry for ...

Pierre Tariot on Closing in on a Blood Test for Alzheimer’s?

COMMENT As the authors state carefully and clearly, these findings need to be replicated, the analytic methods need to be confirmed, ROC performance in other brain diseases is needed, and validation in clinical trials of AB lowering agents is needed. That said, ...

Erik Portelius on Closing in on a Blood Test for Alzheimer’s?

COMMENT It has long since been believed that measures of cerebrospinal fluid Aβ concentrations more likely reflect Aβ metabolism in the central nervous system (CNS). Previous studies on plasma Aβ have been contradictory and most groups have reported no change in ...

Randall Bateman on Closing in on a Blood Test for Alzheimer’s?

COMMENT The authors should be congratulated on developing a highly specific blood test for amyloidosis and demonstrating it so well. It was a fantastic paper that found nearly identical results in performance of a mass spectrometry-based blood test for amyloid ...

Henrik Zetterberg on Closing in on a Blood Test for Alzheimer’s?

COMMENT This is a great paper! For many years, it was hard to get a reliable amyloid biomarker signal from blood and many inconsistent results were published. Many researchers, including us, believed that peripheral production of Aβ (from platelets, hepatocytes, ...

Paul Aisen on There’s No Tomorrow for TOMMORROW

COMMENT It is always very disappointing when a major effort to test an intervention aiming to slow the AD process ends without evidence of efficacy. I am sure that a full analysis of the data collected will nonetheless advance the field; we always learn from ...

Daniela Galimberti on There’s No Tomorrow for TOMMORROW

COMMENT The failure of the TOMMORROW preventive trial is not a surprise. Although the concept that AD has to be prevented rather than cured is innovative and deserves to be pursued in the future, we are far from having tools to select the population to be treated ...

Marcia Ratner on Parkinson’s Risk Genes Add Up to Hasten Disease

COMMENT The subclinical progression and age at onset, as well as clinical progression subsequent to diagnosis of complex age-related neurodegenerative diseases such as PD, is very likely to involve interactions not only between risk genes but also between genes ...

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