8768 RESULTS
COMMENT Ranasinghe et al. report that different clinical phenotypes of Alzheimer’s disease (AD) are associated with different patterns of EEG synchronization abnormalities. The magnetoencephalographic recordings, molecular imaging, and multimodal analyses in this ...
COMMENT This paper is a significant step forward in our understanding of how AD pathology quantitatively manifests at the circuit level. Not only does it confirm and extend recent evidence of altered circuit function in early AD, it also, critically, supports ...
COMMENT I think this study is important, as it may shed light on the function of TMEM106B, which has emerged as a key genetic risk locus not only for development of FTLD-TDP, but also for rate of progression in clinical FTD and in Parkinson’s disease (Tropea et ...
COMMENT This study by Liao et al. describes a rare AD-associated mutation in the ECE2 gene coding for endothelin-converting enzyme-2, a physiologically relevant Aβ-degrading enzyme. In a Chinese family with a high incidence of AD (father and three of six siblings ...
COMMENT While the hunt continues for "small molecule regulators," the use of indirect transcranial and intraocular and intranasal near-infrared photobiomodulation can be used to mitigate cell death and improve ATP production and cortical blood flow. ...
COMMENT This study adds to the growing evidence that even though centenarians have reached advanced ages and thus have the largest risk factor for Alzheimer's disease and related dementias, there are a subset of centenarians who are resistant to dementia. ...
COMMENT This is an interesting study, as are most studies on centenarians. I suspect that these survivors have some unique genetic resilience factors operating. Lifestyle might be part of it, but I am more inclined to invoke a “polygenic resilience” in these ...
COMMENT This interesting study overlooks that PrP, like Alzheimer Aβ (Soscia et al., 2010; Moir et al., 2018), and probably also α-synuclein (Park et al., 2016), is an antimicrobial protein (AMP)—as pointed out by Artur Schmidtchen and colleagues in Sweden ...
COMMENT The two papers by Chow et al. and Grubb et al. significantly advance our understanding of neurovascular physiology and blood flow control. Through a combination of elegant in vivo two-photon imaging, molecular manipulations, pharmacology, and electron ...
COMMENT Grubb et al. provide an excellent structural and functional description analysis of the precapillary sphincters. They express alpha smooth-muscle actin and basement membrane proteins, and their main role appears to be in reducing the perfusion pressure in ...
COMMENT This paper by Gu et al. shows that caveolae in the arterial endothelial cells are required for neurovascular coupling at the level of vascular smooth-muscle cells and arterioles. This is an important and novel finding. It provides new mechanistic insight ...
COMMENT Brian Chow, Vicente Nuñez, and colleagues from Chenghua Gu’s lab at Harvard reveal the molecular mechanisms for a fascinating and fundamental feature of the brain vasculature: How do blood vessels “know” when neurons and other brain cells need more fuel ...
COMMENT Cerebral blood flow (CBF) and the increase in CBF evoked by neuronal activity are reduced early in Alzheimer’s disease (AD) (Iturria-Medina et al., 2016), with the decrease in CBF exceeding 40 percent in affected areas (Asllani et al., 2008). In humans ...
COMMENT The great majority of cases of neurodegenerative disease are not caused by genes. This new paper from the laboratory of S. Mazmanian provides further evidence that amyloid proteins made by gut bacteria play key roles in the initiation of neurodegeneration ...
COMMENT Arakhamia et al. hypothesize that pronase treatment removes PTMs from the ordered cores of tau filaments, which would lead to their absence in resulting cryo-EM structures. However, in Fitzpatrick et al., 2017, we compared cryo-EM structures of the ...
