8901 RESULTS
COMMENT This is a detailed human tissue study that reports on the heterogeneity of pathogenic tau species in spite of near-identical histological scoring of NFTs. While done only in 32 subjects with “typical” AD, it’s already clear that the biochemical and ...
COMMENT It is well established that the severity of cognitive impairment in Alzheimer’s disease correlates with the number of tau inclusions. Brad Hyman played an important part in helping to establish this concept (Hyman et al., 1984; Arriagada et al., 1992; de ...
COMMENT We have halted visits but kept in contact with the centenarians. From our cohort, three centenarians contracted COVID-19; one centenarian was already in a bad condition and he passed, but the other two survived. This is in line with the many reports of ...
COMMENT In response to Alzforum’s question about the status of Alzheimer’s research at the University of Pittsburgh, basic research studies are slowly coming back online. I had the first of two walk-through inspections of my basic science lab to ensure we were ...
COMMENT My months in furlough: A scientist without a lab As an early career researcher, I am interested in the early molecular changes in cellular pathways that lead to the manifestation of neurodegenerative diseases, and study these changes using iPSC-derived ...
COMMENT While the Covid-19 pandemic has affected our research activities, the labs are now returning to their normal operation and the research staff have resumed their experiments. Cell lines and animals have also been well maintained. However, since ...
COMMENT Dujardin et al. found a correlation between the rate of progression of Alzheimer’s disease and the seeding activity of tau extracted from postmortem samples of frontal cortex (Brodmann areas 8-9) in 32 cases. The seeding activity was evaluated in a ...
COMMENT In the early days of research on the role of Tau protein in AD, Brad Hyman and colleagues showed that the distribution of neurofibrillary tangles in the brain was a better predictor of the progression of AD than senile plaques (Arriagada et al., 1992), ...
COMMENT It is an understatement to say that the COVID-19 pandemic has caused significant disruption to basic research at U.K. universities. Most laboratories remain unable to conduct experimental work or are running severely reduced essential operations only, ...
COMMENT These are interesting and rather compelling findings. It is nice to see that antibody-mediated targeting of phospho-tau epitopes, as we have advocated, was most effective under these conditions. It is notable that the phospho-epitopes identified by mass ...
COMMENT There is an entire field of exploration to understand the nature of pathological tau species in AD amongst monomeric, oligomeric, and fibrillary and modified tau species. The study by Dujardin et al. provides new insight to posit that seed-competent tau ...
COMMENT This is a well-designed study underlining once more the importance of soluble tau oligomeric assemblies over long tau filaments in Alzheimer’s disease, as well as heterogeneity in tau oligomers. The findings of this study hold significance as varied tau ...
COMMENT This paper suggests a dual role of TREM2 during disease evolution. Early on TREM2 risk variants increase Aβ toxicity and promote its spreading (see also Parhizkar et al., 2019). Similarly, TREM2 risk variants appear to promote tau spreading in early ...
COMMENT We also have examined a LRKK2 frameshift variant (c.6187_6191delCTCTA; p.L2063fs*) in lymphoblastoid cell lines (LCLs) of an individual affected by amnestic MCI, without Parkinson’s disease (Perrone et al., 2018). The variant was a five-base-pair deletion ...
COMMENT In the etiopathogenesis of synucleinopathies, there is a substantial gap in our understanding of how and when α-synuclein de novo assembles into insoluble aggregates. Genetic and environmental factors have provided strong links between α-synuclein and ...
