8551 RESULTS
COMMENT This is an interesting study that examined whether injecting plasma drawn from exercising mice could benefit the brains of mice that have not exercised. Those mice injected with the “runner plasma” demonstrated greater neuroplasticity, improved learning, ...
COMMENT Chris Dobson was, first and foremost, a terrifically unique person in every way. A great family man and, in his profession, caring, thoughtful, sincere, honest, humble, and always treating everyone he met, no matter who they were, in an even-handed and ...
COMMENT The main claim of this paper is that a drug used to treat prostate overgrowth, terazosin (TZ), may benefit people with Parkinson’s. In particular it may reduce the risk of Parkinson’s, and/or slow its progression. Such a “disease-modifying therapy” would ...
COMMENT The data generated by Tomita’s group supports the emerging view of a highly flexible and dynamic presenilin (PSEN) structure. Recent structural data has highlighted the conformational flexibility of the transmembrane domain (TMD) 2 of PSEN and uncovered ...
COMMENT I knew Chris at the end of 1980s when he was still in Oxford. Since then, for many years I had a stimulating scientific collaboration with him in many aspects of protein folding, misfolding, aggregation, and aggregate toxicity, leading to co-authoring 23 ...
COMMENT In their article, Konttinen et al. write: "[E]xact mechanisms underlying human APOE4-induced inflammatory phenotype in AD microglia remain incompletely defined." Their study and several other recent publications suggest a strong possibility of a ...
COMMENT This very interesting article from lead author Amit Joshi adds to growing evidence that damaged mitochondria may propagate neurodegeneration by triggering neuroinflammation. Mitochondria are bacterial in origin. Their unique proteins, lipids, and circular ...
COMMENT Chris Dobson transformed the field of protein misfolding and aggregation, dramatically advancing our understanding of Alzheimer's disease and related disorders. He pioneered the introduction of powerful chemical and biophysical approaches, reshaping ...
COMMENT I had the privilege of doing my Ph.D. in Chris Dobson's lab. Under his guidance, not only did I learn how to be a better scientist at the lab bench, but also how to conduct myself as a researcher. I am eternally grateful for his kind words and ...
COMMENT After I finished my Ph.D. in Belgium, I was exploring options to do a postdoc. I was particularly interested in advancing the understanding of Alzheimer’s disease and wanted to apply my knowledge of biophysical chemistry to do so. When I discussed this ...
COMMENT One would need many pages to describe just the major contributions provided by Chris Dobson to science. The first significant contribution was on elucidating the principles of protein folding, using a number of proteins as models, such as lysozyme. At the ...
COMMENT Chris Dobson has made a tremendous impact on the field of neurodegenerative disease. His findings that the formation of amyloid fibrils, as well as oligomer toxicity, are grossly sequence-independent have changed the way we think in this field. Chris has ...
COMMENT Chris was a truly exceptional scholar and scientist whose work transformed the study of protein-aggregation diseases, but also a remarkable person whose sharp wit, visionary leadership, and generosity were widely admired. He was a true pioneer, bringing ...
COMMENT I have known Chris Dobson for more than 25 years. He was one of my closest colleagues and a true friend. We got to know each other during a conference in England, and he spontaneously invited me and my wife, Manajit, to come to Oxford to discuss possible ...
COMMENT This is very disappointing news—both for the patients and for drug development using BACE1 as a drug target. A major question that arises from the stopped elenbecestat trials is: What is the nature of the side effects observed? Is it an off-target effect, ...
