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Martin Steger on Does LRRK2 Sweep α-Synuclein from the Cell?

COMMENT We think that the papers are very nice! Eguchi et al. confirm all our recently published findings and they observe an increase in Rab10 phosphorylation upon lysosomal activation, which is very intriguing. This is the very first time that we have seen a ...

Quyen Hoang on Does LRRK2 Sweep α-Synuclein from the Cell?

COMMENT Both Bae et al. and Eguchi et al. show LRRK2 functioning in the endocytic recycling pathway, which is consistent with an earlier study by Mark Cookson’s group showing that LRRK2 interacts with Rab7L1—a protein involved in endosomal recycling (Beilina et ...

Sabine Hilfiker on Does LRRK2 Sweep α-Synuclein from the Cell?

COMMENT Two recent studies report on the role of LRRK2 in altering endolysosomal structure/function and lysosomal secretion, albeit coming to different conclusions. Eguchi et al. used various tissue culture cell lines treated with chloroquine, a lysosomotropic ...

Erik Musiek on Does Cognition Change With the Seasons?

COMMENT This paper builds on work from the same lab showing seasonal variation in brain gene expression, and the data are in keeping with other studies linking seasonality to cognition (Meyer et al., 2016). These findings are very interesting and important, as ...

Matthew Pase on Does Cognition Change With the Seasons?

COMMENT This is a fascinating paper showing seasonal differences in cognition and related biological measures. The authors show that cognitive performance peaks around the time of the fall equinox. The impact of seasonal variation on cognition is large, ...

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