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Takaomi Saido on Striking Microgliosis in New APP Knock-in Mice

COMMENT The new knock-in mice described by Xia and colleagues carry Swedish (NL), Arctic (G) and Austrian (I) mutations (NL-G-I mice) are conceptually identical to our mice that carry Swedish, Arctic, and Beyreuther/Iberian (F) mutations (NL-G-F mice) (Saito et ...

Carlo Condello on Striking Microgliosis in New APP Knock-in Mice

COMMENT Xia et al. present a new APP knock-in (KI) mouse model for Aβ amyloidosis that expresses humanized Aβ with three familial, early onset AD mutations and recapitulates the spatial patterning of plaque deposition observed in humans under physiological ...

Lon S. Schneider on Aducanumab Decision Delayed for Three Months

COMMENT The three-month delay is a political win-win-win for the FDA, Biogen, and the indefatigable advocacy groups. The agency has had the necessary information to decide since November, but is either conflicted or carefully timing an announcement. Their current ...

Christian Haass on Striking Microgliosis in New APP Knock-in Mice

COMMENT This is a mouse model for amyloidosis, which, finally, is freely available for the entire research community. This is a big issue, considering that many experiments were blocked or slowed due to legal issues with mouse models. I think this is a great sign ...

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