9237 RESULTS
COMMENT Abundant filamentous tau inclusions are characteristic of a number of human neurodegenerative diseases, collectively referred to as tau proteinopathies. The presence of inclusions correlates with neurodegeneration and a causal connection became clear ...
COMMENT This paper by Dr. Cara Croft and colleagues is an elegant demonstration that fibrillar tau aggregates in neurons are not static structures in the organotypic brain slice model used. I was particularly interested that the half-life of inclusions was longer ...
COMMENT Targeting Protein Synthesis Translational Control to Treat Dementia. Memory disorders pose a major threat to public health and are responsible for an enormous economic and social burden. Long-term memory formation diminishes with normal aging and among ...
COMMENT This paper provides additional data for the integrated stress response (ISR) as playing an active role in models of neurodegenerative disease. This response pathway both impacts protein synthesis and leads to stress-granule formation. Prior studies ...
COMMENT This study by Floud et al. is a very nice and large study including over 800,000 women followed for approximately 16 years. The women were aged approximately 60 years when information on social and cognitive activity was collected. The social and ...
COMMENT The new knock-in mice described by Xia and colleagues carry Swedish (NL), Arctic (G) and Austrian (I) mutations (NL-G-I mice) are conceptually identical to our mice that carry Swedish, Arctic, and Beyreuther/Iberian (F) mutations (NL-G-F mice) (Saito et ...
COMMENT Xia et al. present a new APP knock-in (KI) mouse model for Aβ amyloidosis that expresses humanized Aβ with three familial, early onset AD mutations and recapitulates the spatial patterning of plaque deposition observed in humans under physiological ...
COMMENT The three-month delay is a political win-win-win for the FDA, Biogen, and the indefatigable advocacy groups. The agency has had the necessary information to decide since November, but is either conflicted or carefully timing an announcement. Their current ...
COMMENT This is a mouse model for amyloidosis, which, finally, is freely available for the entire research community. This is a big issue, considering that many experiments were blocked or slowed due to legal issues with mouse models. I think this is a great sign ...
COMMENT We do not know which information FDA requested of Biogen. I do not believe the new data from the ongoing open-label extension trial on aducanumab represent significant information because of the uncontrolled nature of the study. Rather, I can speculate ...
COMMENT Although genome-wide association studies (GWAS) have been pivotal at increasing our understanding of the genetic basis of AD, it has remained challenging to understand what the effect is of an implicated variant (i.e., which gene it affects). Novel ...
COMMENT How AD genetic risk variants eventually lead to dementia is a difficult but important topic of research. Wingo and colleagues took a PWAS approach to study relationships between AD genetic risk variants and abundances of 1,475 proteins quantified in the ...
COMMENT The beauty of standard genome-wide association studies is the simplicity of the analysis pipeline … a high (p) value is required for Bonnferroni correction, but, once that is past, the result is credible and reproducible. However, the very high correction ...
COMMENT Imaging technologies have advanced so much over the last 10-15 years and our knowledge of how different cell types interact with one another in the brain —within living animals—has sharply increased during this time. This is no coincidence. Along this ...
COMMENT This is a very interesting study that examines the structural and functional consequences of neuroinflammation within the mouse cortex to provide novel insights into the pathophysiology of multiple sclerosis (MS), an inflammatory disease of the central ...
