7942 RESULTS
COMMENT It's good to see the excitement about the role of herpes viruses in AD elicited by the studies of Readhead et al. and Eimer et al., and good to know that the discovery, 28 years ago, of HSV1 DNA in elderly human brains by simple PCR (Jamieson et al., ...
COMMENT This paper by Eimer et al. and also Readhead et al., 2018, are both really exciting. I speculate that in years to come, people will remember them as the beginning of a new era in AD research. In the field of late-onset disorders of the brain, we have long ...
COMMENT In this paper the Petrucelli lab extend their previous work by generating new viral-mediated models of poly-glycine-arginine (GR) expression in mice. The group has previously demonstrated that overexpression of sense-direction 66 repeat RNA via ...
COMMENT Does anyone think it's significant that seven of 12 genes shown to be upregulated in cells harboring latent HSV-1 are also upregulated in Alzheimer's patients brains? (See lists of each below). Eight Genes Upregulated in Alzheimer's Brain ...
COMMENT GABAA receptors, among the most predominant inhibitory receptors in the central nervous system, constitute heteromeric structures formed by the assembly of five subunits, the most common of which are α, β, γ, δ. These subunits host a number of binding ...
COMMENT This paper provides compelling support for the antimicrobial protection hypothesis of Alzheimer's disease. It's not yet clear whether herpesviridae represent a causative factor in Alzheimer's disease etiology. Even so, the discovery that ...
COMMENT This paper offers convincing evidence that active HSV-1 and HHV-6 infections in 5XFAD mice and human neural cell cultures induce Aβ fibrillization, adding further weight to the argument that Aβ counts antimicrobial peptide activity among its pleiotropic ...
COMMENT This paper properly highlights the anti-infective AMP nature of Aβ amyloid. These data, with previous work from this and other laboratories, provide a rationale as to why amyloid would accumulate in the Alzheimer’s brain, as well as in brain in other ...
COMMENT The authors have devised an extraordinarily creative hypothesis. The concept that Aβ fibrils can act as pathogen nets—ensnaring and then trapping herpesviruses—is remarkable and unanticipated. This direct link between Aβ and immunity is compelling; ...
COMMENT Our study, taken together with the Readhead et al. findings, suggest a new model for amyloidogenesis in which chronic elevated viral replication may directly promote Aβ deposition in AD brain. In this model, the activation of herpes viruses serves to ...
COMMENT The manuscript by Zhang et al. provides a new model for the study of C9ORF72, and in the process provides useful insight into common pathways that appear to mediate neurodegeneration in ALS and related disorders. Previously, Petrucelli’s group showed that ...
COMMENT Zhang et al. report neurodegeneration and behavioral changes in the first poly(GR) mouse model using their AAV-based expression system. Strikingly, these mice show no TDP-43 pathology, suggesting that DPRs also trigger TDP-43-independent pathways of ...
COMMENT This paper places another important puzzle piece. Arginine-containing poly-dipeptides (PR and GR) produced in C9-ALS/FTD are exquisitely toxic in a wide variety of model systems, including HeLa cells (Kwon et al., 2014), cultured neurons (Wen et al., 2014 ...
COMMENT This new paper reports the first mouse model expressing specifically poly(GR), which is an exciting step forward for the field. This was achieved by expressing 100 GFP-tagged poly(GR) repeats in the mouse brain using AAV. The mice show diffuse cytoplasmic ...
COMMENT This is an interesting study using incredible resolution to assess localization of Aβ. It supports data from our group and others that a lot of Aβ is made presynaptically. Our in vivo data suggest that 70 percent of Aβ (40 and 42) found in the ...
