8637 RESULTS
COMMENT This manuscript by the Heneka lab dissects the influence of inflammasome activation on tau pathology in a mouse model of tauopathy. The notion that exacerbated inflammatory responses can accelerate tau pathology ties in with previous reports indicating ...
COMMENT Alzheimer’s disease is characterized by extracellular deposition of Aβ and intraneuronal accumulation of hyperphosphorylated tau protein. Previous studies showed that dementia correlates well with tau, but not with Aβ burden, indicating that tau ...
COMMENT The paper by Ising et al. is a very important contribution to defining the deleterious roles of microglial activation in promoting tau pathology. It adds to these authors’ prior data finding analogous influences of inflammasomes upon amyloid pathology in ...
COMMENT Ma and colleagues have published an impressive study which examines the relationship between visit-to-visit blood-pressure changes and incident dementia. The results of this study highlight the importance of examining longitudinal blood pressure ...
COMMENT Several studies have unveiled an important phenotypic heterogeneity of mouse microglia. Yet our understanding of the human microglia is limited, especially because of the technical difficulties to obtaining fresh brain tissues from human donors. ...
COMMENT This paper takes the field closer to NLRP3 as a target for a therapeutic intervention in AD. The previous data from Michael Heneka's lab showing a role for NLRP3 in amyloid seeding already suggested it as a target (Venegas et al., 2017). The ...
COMMENT Nott, Holtman, Coufal, and colleagues have produced a tremendous resource by applying several chromatin assays to purified human brain cell types. This builds on their previous work, which was the first to investigate the gene regulatory landscape of ...
COMMENT The current work from the Glass lab provides striking evidences that a significant number of SNPs associated with LOAD likely affect gene expression exclusively in microglia. In particular, in the context of BIN1, the present work confirms what we ...
COMMENT This is an extraordinary study that provides a final piece of evidence for the causal involvement of microglia in Alzheimer’s disease. This work follows up a previous report from the same group, where the authors performed transcriptomic analysis of human ...
COMMENT The intriguing and encouraging results of the GV971 trial could be explained by an alternative—or perhaps additional—mechanism: the protective effect against AD might well be the consequence of the drug acting as an antiviral agent against HSV1, which has ...
COMMENT This is an interesting study providing useful data for the understanding of brain endothelial function in both physiological and pathological conditions. The study shows that in different models of neurodegenerative diseases, the transcriptional responses ...
COMMENT This exciting study provides a comprehensive data resource on the molecular underpinnings of brain endothelial cell dysfunction. It builds on the group's prior work providing a healthy blood-brain barrier (BBB) transcriptome, an already incredibly ...
COMMENT This is a noteworthy study by the Daneman lab comparing the transcriptional profiles of mouse blood-brain barrier (BBB) endothelial cells (ECs) with those in other organs of the body (i.e., heart, lung, kidney, and liver) using RNA-Seq method and an ...
COMMENT This is an exciting paper from the Daneman group that studies how the unique characteristics of endothelial cells (ECs) around brain capillaries change in different types of pathology, in such a way that the ECs start to resemble ECs on peripheral ...
COMMENT The authors should publish the full study as soon as possible. The observed effect size is relatively small, and is only slightly greater than the minimal clinically important difference of ADAS Cog. So, I don't view this as a breakthrough. If they ...
