8066 RESULTS
COMMENT This is a very interesting study that puts together a potential mechanism linking C9ORF72 dipeptide protein aggregates with TDP-43 pathology. By delineating a sequence of events in the fly model involving karyopherin dysfunction and initial TDP-43 mis ...
COMMENT This paper from Soloman et al. addresses an important problem in C9ORF72 disease research to date. Dipeptide-repeat (DPR) proteins are observed to be extremely toxic in cell and animal models, and TDP-43 pathology correlates with neuronal loss in ...
COMMENT Since most people do not get sufficient exercise, it would be interesting to determine if exercise-induced changes in expression levels of antioxidant enzymes such as glutathione-S transferase play a role in the protection observed in this study. Such ...
COMMENT This fully powered, 18-month study of nilvadipine (NILVAD) by Brian Lawlor and colleagues in persons with clinically diagnosed AD dementia failed to show any cognitive or functional benefits of NILVAD. The trial was well-designed and the published report ...
COMMENT There was a strong rationale for this trial, considering the strength of the preclinical studies suggesting improvement of amyloid pathology in mouse models, and the evidence from observational studies in humans, leaning toward cognitive improvement. The ...
COMMENT Both these papers are important because they open up new lines for investigating the impact of aging-related neurodegenerative diseases, and we know so little about how mechanisms of aging interact with or contribute to mechanisms of neurodegeneration. ...
COMMENT The article by Müller and colleagues provides compelling cross-sectional data on the relationship between physical activity, cognition, functional ability, and Alzheimer’s disease biomarkers in an autosomal-dominant AD population. As the authors stated, ...
COMMENT The paper is interesting and is consistent with a lot of other research that seems to indicate a protective association between exercise and the risk of AD, dementia, and cognitive performance. It's a bit different in that the population involves ...
COMMENT The paper by Mueller et al. demonstrates for the first time the existence of an association between self-reported physical activity and cognitive status even in patients with Alzheimer’s disease of genetic origin. The paper is interesting and well ...
COMMENT This is a study the entire field has been waiting for, for a long time. After the initial finding that BACE1 is required for myelination via neuregulin 1 processing back in 2006 (!) (Hu et al., 2006; Willem et al., 2006), a number of other substrate ...
COMMENT This study provides unique and important results in that it combines both cross-sectional and longitudinal biomarker data to map the pathogenesis of autosomal dominant AD. It also shows that the advantage of using longitudinal measures differs depending ...
COMMENT Yet another major contribution from DIAN. The investigators conducted a comprehensive longitudinal biomarker study in volunteers around the world who do or do not have autosomal dominant mutations that cause onset of Alzheimer’s symptoms at a generally ...
COMMENT Fred van Leeuwen continues his frame-shifting thinking with further findings on how a UBB +1 transgene could slow brain amyloid accumulation in ADtg mice. This story began 35 years ago with studies on the Brattleboro rat, which has congenital polyuria due ...
COMMENT The recent structural studies illuminate that Pick’s disease is picky in selecting a repeat to fold into tau aggregates. Falcon and colleagues have demonstrated an exciting difference at the molecular level between Alzheimer’s disease and Pick’s disease ...
COMMENT To iron out a few kinks in Alzheimer’s disease field, Lumsden et al. have built an iron framework that might unite, functionally, several known mutations associated with the familial form of AD. It is timely and thought provoking. The “traditional” ...
