9013 RESULTS
COMMENT I am saddened to see the loss of another colleague from the early days of Alzheimer's research. His identification of a neurotransmitter change in Alzheimer's disease in 1976 offered the hope we could soon develop a pharmacological strategy for ...
COMMENT I am profoundly saddened to learn that Peter Davies passed away. I've always had tremendous respect for Peter, both as a scientist and a person. He was an extraordinarily gifted researcher, brilliant thinker, and a man of genuine warmth and ...
COMMENT This study showed a significant impact of sodium phenylbutyrate/taurursodiol on ALS, based on slowing of the rate of decline in subjects versus controls as measured by the ALSFRS-R, a primary assessment tool for measuring functional change. Overall, there ...
COMMENT BrightFocus is mourning the loss of Dr. Peter Davies. We are especially proud and grateful to have had him serve as a member of our Alzheimer’s Disease Research Scientific Review Committee from 1989 to 2000, and co-chair for six of these years. His ...
COMMENT It is with profound sadness that I learned of the death of Professor Peter Davies. What terrible news. Peter was a mentor to many of us. A pioneer in the cholinergic hypothesis, he was quickly interested in tau protein. He then became a leader in the tau ...
COMMENT A synthetic synaptic organizer protein restores glutamatergic neuronal circuits This is a remarkable study that proposes the novel concept that a synthetic molecule that assembles pre- and postsynaptic regions in central synapses can promote the formation ...
COMMENT There are those who have known Peter since the discovery of Tau and those, like me, who met him only a few years ago. Yet despite the different time frame, we all use similar words to describe him: gentle, kind, encyclopedic, great debater, even-tempered, ...
COMMENT Interaction with membranes represents a crucial aspect of the physiology of α-synuclein (αSyn). As far as pathology is concerned, excess vesicle interaction has been proposed to trigger αSyn aggregation via primary nucleation (Galvagnion et al., 2015). In ...
COMMENT These papers by Deniston et al. and Watanabe et al. constitute significant advances in our understanding of LRRK2 structure and function. Previous insight into LRRK2 structure came through biomolecular modeling studies, three-dimensional structures of ...
COMMENT This study by Cook et al. nicely builds on many years of work documenting the effects of the C9ORF72 G4C2 expansion and dipeptide repeat (DPR) proteins in vivo. Previously, it was shown that expressing the G4C2 repeat leads to RNA foci, DPRs and TDP-43 ...
COMMENT This paper by Zhang et al. elegantly builds upon, and strengthens, their previous findings that progranulin is required to suppress aberrant microglial activation in the aging brain (Lui et al., 2016). For many years microglia had been overlooked as ...
COMMENT We read the study by Hur et al. from Dr. Yue-ming Li’s group with great interest and are impressed with their insightful discoveries on IFITM3. Previously, we uncovered a type I interferon response in brains harboring amyloid plaques from both mouse ...
COMMENT This paper by Cook et al. describes very exciting results. The authors present strong evidence that poly(GR) promotes TDP43 pathology indirectly by inhibiting its nuclear transport and more directly through physical interaction promoting TDP43 aggregation ...
COMMENT This impressive new paper from the Petrucelli group presents a unified hypothesis linking key molecular phenotypes of C9ORF72-ALS to a single mechanism. They present evidence that poly(GR) protein translated from the C9ORF72 expansion can accelerate the ...
COMMENT The origin and meaning of TDP-43 aggregation in neurodegenerative disorders such as ALS and FTD remain a mystery. TDP-43 undergoes physiology aggregation and disaggregation, and, as an RNA-binding protein, traverses in and out of the nucleus. Somehow in ...
