8901 RESULTS
COMMENT This paper is from one of the top groups worldwide for this type of work. The cohort is one of the major studies that has been ongoing for years. The findings are important, in that they reinforce the importance of mentally stimulating activity relatively ...
COMMENT In this paper, Yang et al. present a novel method of labeling whole panels of plasma proteins to measure BBB permeability in the aging mouse. By labeling endogenous blood-plasma peptides, they were able to specifically measure physiological rates of ...
COMMENT Dementia researchers have long been intrigued by reports that early life experiences can influence the risk of dementia later in life. Much of the work has related to education or socioeconomic status as proxies of this experience (Valenzuela et al., 2007 ...
COMMENT I find this paper very exciting for a few reasons: Rodent models of enriched environments have long been explored as moderators of neurodegenerative disorders (Nithianantharajah and Hannan, 2006), The notion of cognitive reserve was, until recently, ...
COMMENT A large body of research has focused on identifying protective lifestyle factors that may enhance cognitive resilience against the effect of primary Alzheimer’s pathology on cognition, but only little is known about those factors that may slow down the ...
COMMENT We very much appreciate the attention given by Alzforum to our recent paper. Concerning Dr. Ransohoff's comments on statins and RhoGTPases, we would like to draw attention to the following: 1. Besides RhoA, statins impact several other signaling ...
COMMENT This is a nice story. The technology developed is very impressive, as well. Basically, the investigators developed a single-cell, targeting ablation technology using two-photon-mediated photochemically induced apoptosis (2Phatal) to promote apoptosis only ...
COMMENT The Grutzendler group visualized spatiotemporal resolution of efferocytosis including sensing, engulfing and digesting the neuronal corpse by microglia and astrocytes by photochemically and virally induced single-cell-targeted ablation of neurons in the ...
COMMENT Our knowledge about the diversity of cellular phenotypes and responses in the brain has increased substantially in recent years due to advances in single-cell analysis and other approaches. In line with this, there is an increasing need to uncover the ...
COMMENT The sophisticated “2Phatal” technique developed by Jaime Grutzendler's group has allowed them to investigate how dead neurons are cleared in vivo in real time. Damisah, Hill and colleagues show that after inducing apoptosis in specific neurons by ...
COMMENT Tsai and colleagues present several converging lines of evidence to bring new insight to the role of ApoE and calcineurin–nuclear factor of activated T cells (NFAT) signaling in cerebral amyloid angiopathy (CAA) and Alzheimer’s disease (AD). Evidence to ...
COMMENT We read this article with great interest. This work provides a convincing confirmation of the value of TREM2 agonist antibodies in mouse models of AD while providing new details on the impact of these antibodies on microglial state through single-cell RNA ...
COMMENT The group of Jaime Grutzendler has recently developed a cutting-edge technique, 2Phatal, allowing researchers to induce apoptosis of individual neuronal cells using a photochemical reaction. From the same group, Damisah and colleagues now took advantage ...
COMMENT This is a very interesting study from the perspective of trans-differentiation of mature cells into other cell types. The data generated here depends heavily on the use of transgenic mice, introducing potential confounding factors such as promoter leakage ...
COMMENT In our paper, now in press at Mol. Neurodegeneration, we argue that the repeat domain of Tau, when coupled to GFP, cannot form amyloid-like Tau filaments because of steric hindrance. GFP is too big to fit onto the tight cross-β structure of an amyloid ...
