SEARCH RESULTS

9104 RESULTS

Charles Stromeyer on Does Astrocyte Tau Cause Dementia?

COMMENT A recent study in Nature finds that microglia sense ATP and then inhibit neuronal activity (Badimon et al., 2020). Thus, if there is less ATP production by astrocytes then maybe there is also less inhibition by microglia? Additionally, another new Nature ...

Fuyuki Kametani on In Mice, Aducanumab Neutralizes Aβ Seeds

COMMENT Suppressing or slowing the progression of AD is thought to be a pathological condition shown in the reference paper. It has been shown that even if Aβ is deposited, disease onset can be suppressed or delayed by suppressing the spread of tau pathology. ...

Thomas Vogels on Does Astrocyte Tau Cause Dementia?

COMMENT This is a very intriguing and detailed analysis regarding the functional consequences of 3R tau in astrocytes. It is an important reminder that much remains to be learned about the functional consequences of pathological tau in astrocytes. Several older ...

Eileen Press on In Mice, Aducanumab Neutralizes Aβ Seeds

COMMENT I hope that this experiment can be repeated in a human CD33 transgenic mouse that has been crossed into an Alzheimer's model. There is strong unpublished evidence to suggest that CD33 is involved in the regulation of the phagocytosis or trogocytosis ...

Justin Sanchez on Does Astrocyte Tau Cause Dementia?

COMMENT This elegant study by Richetin and colleagues has several interesting and important findings. In human participants with Alzheimer's disease, 3R tau accumulation was observed in astrocytes in the hippocampus, specifically the hilus of the dentate ...

Josh Morganti on Does Astrocyte Tau Cause Dementia?

COMMENT This is a very interesting study that highlights the susceptibility of astrocytes to preferentially acquire pathological features in the form of confirmation-specific isoforms of tau in hippocampal regions burdened by Alzheimer pathology. Seeking to ...

Current Filters

  • TYPE: Comment x

Remove all filters

Filter By

DATE RANGE
  • All
  • Past 7 Days
  • Past 30 Days
  • Past 90 Days
  • Past 12 Months
  • Specific Dates
    1. From
      To

TYPE