8768 RESULTS
COMMENT As of Tuesday, we have had to shut down all lab operations except for those that are essential. For us that would only be ensuring the cryotank with all our cell lines is kept in liquid nitrogen and minus 80 freezers maintain temperature. No experiments ...
COMMENT The COVID-19 pandemic has thrown quite a wrench in the research works, but we're adapting around it and accepted that some studies will need to be sidelined for a bit. Since Illinois is in a mandatory “shelter in place” order, our university has ...
COMMENT Much study on C9ORF72-ALS has centered on toxicity mediated by dipeptide repeat proteins translated from the GGGGCC-repeat expansion. Despite this work, a fundamental question has remained over the relative absence of dipeptide-repeat protein pathology in ...
COMMENT This paper presents SERP1 as a direct modulator of γ-secretase activity under ER stress, and highlights a potential pathogenic role for the SERP1-mediated upregulation of Aβ production in diabetes and in Alzheimer’s disease (AD). The authors convincingly ...
COMMENT These findings about SERP1 are interesting from a cell biology/protein handling perspective, and they introduce novel ways of thinking about how cellular metabolism and stress can influence protein handling and signaling cascades. The authors present a ...
COMMENT Jung et al. have discovered SERP1, a facilitator for the assembly of the γ-secretase complex and the generation of amyloid β protein (Aβ). They did an excellent job in dissecting the molecular architecture of SRRP1-APH1A/Nicastrin, and provided detailed ...
COMMENT The finding that early changes in soluble tau, including increased phosphorylation, start in parallel with Aβ aggregation is very interesting. This shows how closely integrated the key hallmarks of AD are, even in the earliest stage of the disease. It is ...
COMMENT The paper from De Rossi and colleagues reporting roles of neuronal BIN1 in regulation of presynaptic neurotransmitter release and memory consolidation is of substantial interest. BIN1 is expressed in neurons, microglia, and other non-neuronal cells within ...
COMMENT This is an excellent study that provides novel and convincing evidence for BIN1 acting in regulating release probability at presynapses. Synapses are increasingly seen as the vulnerable early targets in AD, and determining molecular mechanisms by which ...
COMMENT Genetic variants near BIN1 are important risk factors for AD dementia, where the SNP rs744373 is the second most strongly associated genetic locus for sporadic AD after the ApoE ε4 allele. Despite these strong genetic associations of BIN1 with AD ...
COMMENT This paper highlights some striking observations: 1) Alpha rhythm hyposynchrony is specifically related to both Tau burden and cognitive state; 2) The left hemisphere is the main affected brain region in Alzheimer’s disease; 3) Delta/theta synchrony has a ...
COMMENT The general message that a noninvasive neurophysiological technique can provide that much relevant information on molecular AD pathophysiology based on just one minute of data is quite baffling, and illustrates the growing relevance of MEG for clinical ...
COMMENT As the authors indicate, this has important implications for lab modelling of synucleinopathies. It would seem relatively important to be able to show whether the types of assemblies we use in the lab are at all related structurally to those extracted ...
COMMENT This is an elegantly designed study using multidomain imaging to better understand network dysfunction in Alzheimer’s disease and their relationships to phenotype. At a general level, this study adds to the literature on the value of neurophysiological ...
COMMENT Based on the findings that theta/alpha (4-12 Hz) coherence is enhanced between brain areas during spatial memory tasks in rodents, one could hypothesize that disruptions in theta/alpha synchrony or coherence may occur in situations of memory dysfunction ...
