9231 RESULTS
COMMENT Plasma p-tau231 is a welcome measure in the growing list of highly specific blood-based measures. The comprehensive analysis to amyloid and tau PET as well as CSF and neuropathology are great strengths of this study, as are the number of cohorts evaluated ...
COMMENT Ashton et al. provide a very complete picture of the performance of p-tau231, including technical validation. What truly stands out is the stepwise increase of p-tau231 per amyloid-PET quartile and per pathology-confirmed Braak stage, which we did not ...
COMMENT Plasma p-tau has the potential to revolutionize the diagnostic work-up of Alzheimer’s disease in the near future. Plasma p-tau181 and p-tau217 can with very high accuracy differentiate AD dementia from other neurodegenerative diseases, with similar ...
COMMENT This is a great study and another proof of concept that human IPSC-derived culture/organoid systems, although not perfect since not recapitulating fully what is happening in vivo, are providing better models of human physiology and will be useful to gain ...
COMMENT Emerging evidence strongly supports that neural-glial interactions play a pivotal role in Alzheimer's disease pathogenesis. However, there are few human cellular models for studying these interactions. Lorenz Struder's team described a fully ...
COMMENT This interesting study from the Studer lab establishes a defined and modular triculture model of hPSC-derived neurons, astrocytes, and microglia that is useful to study cell-cell interactions and cell-type-specific disease contributions in the context of ...
COMMENT This paper from Oliveira et al. shows exciting data in AD mouse models that add to the growing body of evidence for repressed protein synthesis rates contributing to memory failure and neuronal loss in neurodegenerative diseases. Critically, it further ...
COMMENT There are several highlights of the study that are noteworthy. In the non-PD control group, it was impressive that dyskinesia false-positive rates were so low (~2 percent overall) since these movements are more heterogeneous and can mimic normal functions ...
COMMENT This is a really interesting paper and provides a potentially very useful new tool for studying tau inclusions. Whilst tau tangles have long been reported as a key feature in Alzheimer's disease and other tauopathies, we know surprisingly little ...
COMMENT Abundant filamentous tau inclusions are characteristic of a number of human neurodegenerative diseases, collectively referred to as tau proteinopathies. The presence of inclusions correlates with neurodegeneration and a causal connection became clear ...
COMMENT This paper by Dr. Cara Croft and colleagues is an elegant demonstration that fibrillar tau aggregates in neurons are not static structures in the organotypic brain slice model used. I was particularly interested that the half-life of inclusions was longer ...
COMMENT Targeting Protein Synthesis Translational Control to Treat Dementia. Memory disorders pose a major threat to public health and are responsible for an enormous economic and social burden. Long-term memory formation diminishes with normal aging and among ...
COMMENT This paper provides additional data for the integrated stress response (ISR) as playing an active role in models of neurodegenerative disease. This response pathway both impacts protein synthesis and leads to stress-granule formation. Prior studies ...
COMMENT This study by Floud et al. is a very nice and large study including over 800,000 women followed for approximately 16 years. The women were aged approximately 60 years when information on social and cognitive activity was collected. The social and ...
COMMENT The new knock-in mice described by Xia and colleagues carry Swedish (NL), Arctic (G) and Austrian (I) mutations (NL-G-I mice) are conceptually identical to our mice that carry Swedish, Arctic, and Beyreuther/Iberian (F) mutations (NL-G-F mice) (Saito et ...
