8551 RESULTS
COMMENT Better Than Coffee: A More Specific Adenosine A2A Receptor Antagonist Shows Preclinical Promise Against Neurodegeneration in Alzheimer’s Disease and Other Tauopathies This team led by Dr. David Blum has been pursuing specific adenosine A2A receptor (A2AR) ...
COMMENT This is an intriguing paper showing that abnormal upregulation of neuronal A2A receptors accelerates tau pathology and spatial memory impairment in a tau model. Of particular interest is the demonstration that an abnormal neuronal phenotype is able to ...
COMMENT This large study has better clarified both that there is indeed a behavioral variant of Alzheimer’s disease and that more anterior pathology underpins this variant. There are at least four variants of AD—the more typical amnestic variant, logopenic ...
COMMENT In this manuscript, “An atlas of cortical circular RNA expression demonstrates clinical and pathological associations with Alzheimer disease,” Dube et al. evaluated parietal RNA-Seq data from 13 control and 83 AD samples from Washington University and an ...
COMMENT Since LRRK2 plays a role in controlling the immune response of dendritic cells to Aspergillus, polymorphisms in this kinase could be responsible for a subpar immune response to fungi that permits CNS infection, leading to Parkinson's disease as the ...
COMMENT This is an interesting approach to obtain additional information from amyloid PET scans beyond dichotomization (A+/-) or a composite measure of amyloid PET signal. This fits a series of studies taking alternative approaches to increase the predictive ...
COMMENT This manuscript by Koscik et al. on amyloid duration—or “chronicity”—presents an innovative and valuable approach to a well-trodden research question: How can we best model brain amyloid accumulation to analyze its associations with tau pathology, ...
COMMENT Chris Dobson has made major contributions that have helped shape our current understanding of the normal and aberrant behavior of proteins. His research primarily concerned the fundamental principles that regulate the folding, misfolding and aggregation ...
COMMENT This interesting paper by Kaufmann and colleagues suggests that a number of common brain disorders are associated with potentially accelerated aging of the brain based on neuroimaging. By comparing the structure of control aging brains with those of ...
COMMENT The work from Joshi et al. provides an interesting mechanistic hypothesis to explain how multiple cell types may contribute to several different neurodegenerative diseases. That non-neuronal cells contribute to neuronal cell loss probably has been best ...
COMMENT In agreement with several of the statements above, the clinical trial failure of BACE does not take away the importance of Aβ and senile plaques as key initiators of AD-associated dementia. I will emphasize that these disappointments are due to toxicity ...
COMMENT Singleton et al. show that Alzheimer’s disease, which typically leads to an amnestic dementia, can also have behavioral variants and that the determinant of the phenotype is the anatomy of the neurodegeneration. Similar patterns of heterogeneity were ...
COMMENT Rik Ossenkoppele and co-authors have extended their previous study (Ossenkoppele et al., 2015) using functional metabolic measures. Whereas structural MRI does not significantly distinguish between bvAD and typical AD, metabolic PET and connectivity have ...
COMMENT The observation of anti-inflammatory and thus beneficial effects of “runner plasma” on the brain in young male mice is interesting. The reported molecular mechanisms of an increase in complement cascade inhibitors including clusterin, induced by running, ...
COMMENT This is a very interesting study showing that plasma derived from mice after four weeks of running can enhance adult hippocampal neurogenesis and memory function in sedentary mice. These findings are consistent with recent studies showing that peripheral ...
