27 RESULTS
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COMMENT Growing evidence suggests that maintaining a physically active lifestyle may be particularly beneficial in reducing the risk for dementia and Alzheimer's disease. In this paper, Soto et al. convincingly show that exercise in aging mice preserves the ...
COMMENT Impaired clearance of Aβ is a key contributing factor to Aβ accumulation in the brain and the progression of AD. Studies focusing on Aβ clearance mechanisms, regulation of Aβ efflux, and ways to modulate Aβ removal are of importance to the field. The ...
COMMENT The brain’s microenvironment is strictly maintained by specialized highly vascularized barriers, including the blood-brain barrier (BBB) in the brain parenchyma and the blood-cerebrospinal fluid barrier (BCSFB) in the choroid plexus. Brkic et al. present ...
COMMENT This study by Zenaro and collaborators focuses on the role of neutrophils in Alzheimer’s disease. These are a type of phagocytotic immune cell that act as first-line defenders to fight inflammation. Studies have observed an increase in neutrophils in AD ...
COMMENT We really appreciate Dr. Ando and colleagues' comments. Without any doubt, PICALM has multiple functions besides Aβ clearance via the blood brain barrier that can be linked to AD, such as mitigating Aβ toxicity in neurons (Treusch et al., 2011), ...
COMMENT It is becoming more appreciated that damage to microvessels and the blood-brain barrier may kick-start Alzheimer’s disease (AD) progression. In fact, ailments affecting the neurovasculature, such as cardiovascular disease, hypertension, stroke, and ...
COMMENT The choroid plexus (CP) is a highly vascularized organ embedded in the cerebrospinal fluid (CSF) of the brain ventricles. The CP epithelium contributes to the production and formation of the CSF and is positioned between the two fluid compartments of the ...
COMMENT This study importantly adds to our knowledge that passive clearance pathways from the brain interstitial and cerebrospinal fluid could potentially play an important role in clearing toxic molecules from the brain. This is in addition to previously ...
COMMENT We are delighted that this paper generated so much interest. We believe that our findings show that our novel multimodal RAGE blocker inhibits multiple pathogenic pathways in a mouse model of Alzheimer’s disease, as well as in different cell types in ...
COMMENT This important paper by the Holtzman group establishes the relationship between ApoE4 genotype and decreased clearance of the Alzheimer’s disease (AD) toxin amyloid-β peptide (Aβ) from brain, both in humans and animal models. The idea that ApoE4 ...
COMMENT This is an important study focusing on cerebrovascular dysfunction as a key target of Aβ pathogenic effects. Constantino Ladecola and colleagues have been studying for several years the role of oxidative stress in cerebral vessels, and more specifically, ...
COMMENT Comment by Berislav Zlokovic —Posted 5 March 2003. The paper by Meyer-Leuchmann et al. uses transplant biology to provide convincing evidence that CNS transport of soluble Aß is a major factor implicated in amyloid formation and neurotoxicity. The ...
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