27 RESULTS
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COMMENT This is an elegant and comprehensive study that describes development of an engineered Fc fragment (called a transport vehicle, TV) that binds to the apical domain of the human transferrin receptor (TfR) at the blood-brain barrier (BBB) at a TfR site that ...
COMMENT This paper by Gu et al. shows that caveolae in the arterial endothelial cells are required for neurovascular coupling at the level of vascular smooth-muscle cells and arterioles. This is an important and novel finding. It provides new mechanistic insight ...
COMMENT These papers by Senatorov et al. and Milikovsky et al. demonstrate that BBB dysfunction initiates neuronal dysfunction, supporting the growing body of evidence that BBB breakdown contributes to synaptic dysfunction, neurodegeneration, and cognitive ...
COMMENT Vasoactive properties of peptides have been known for more than 20 years. For example, in the mid-1990s Aβ peptides were shown to induce vasoconstriction in the isolated rat aorta, which was ameliorated by superoxide dismutase 1 (SOD1) implicating ...
COMMENT Previous work has shown that the cerebral blood vessel system and the blood-brain barrier play a major role in regulating the composition of brain interstitial fluid and the distribution of molecules within the CNS, which is required for proper neuronal ...
COMMENT This is a very important paper showing the mechanism underlying the link between dietary salt and cognitive function through endothelial-mediated regulation of cerebral blood flow responses. In an elegant series of experiments, Dr. Iadecola’s team has ...
COMMENT In 1787, anatomist Paolo Mascagni published an atlas of all lymphatic vessels in the human body, which included the brain, where he described the presence of lymphatics in the cerebral dura mater (Mascagni, 1787, Vasorum Lymphaticorum Corporis Humani ...
COMMENT There is increasing evidence that enlarged perivascular spaces (PVSs) are associated with cerebrovascular dysfunction, as well as with cognitive decline and dementia. Using combined T2-weighted fluid attenuated inversion recovery (FLAIR) and T2*-weighted ...
COMMENT Machuca-Parra and colleagues present an interesting study showing that Notch3 signaling is linked to vascular smooth muscle cells (VSMCs) coverage in retinal vessels and demonstrate that restoring Notch3 signaling via genetic rescue and using a Notch3 ...
COMMENT Park and colleagues have put together an elegant study that links activation of perivascular macrophages (PVMs) with known effects of Aβ on vascular function. Importantly, they have identified PVMs as cells responsible for a significant portion of ...
COMMENT Damisah et al. identified an incredibly useful methodology using Nissl dye NeuroTrace 500/525 to specifically label pericytes in vivo, which will more easily allow investigation of pericytes in the living brain. They should be congratulated for this ...
COMMENT In response to Dr. Grutzendler’s comments, we would like to emphasize that two recent exceptional papers (Mishra et al., 2016; Biesecker et al., 2016) from two different groups have independently confirmed the role of pericytes in neurovascular coupling, ...
COMMENT Aquaporin-4 (Aqp4) is a major water channel in the human brain, located mainly in the astrocytic end-feet around cerebral blood vessels. Aqp4 plays a number of physiological roles in brain, including regulation of extracellular space volume, and ion and ...
COMMENT Iturria-Medina and colleagues provide definitive confirmation of two facts about the Alzheimer's pathophysiological cascade that have been underappreciated, despite cumulative evidence from several groups: First, that memory dysfunction may occur ...
COMMENT Both Berezuk et al. and Suzuki et al. focus on the often-neglected role of the Virchow-Robin spaces that control the rate of bulk flow of brain interstitial fluid (ISF), including clearance of potentially toxic substances from brain. Therefore, changes in ...
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