206 RESULTS
COMMENT This work provides a valuable new model for familial tauopathies because it appears to provide important features lacking in other models. Specifically, these tau inclusions occur in the forebrain, unlike transgenic mice carrying P301L tau driven by the ...
COMMENT There is an increasing connection between cholesterol and APP/Aβ. This is a provocative hypothesis. While it is likely that the toxicity of Aβ is pleitropic, the proposition that Aβ plays a role in cholesterol transport appears reasonable. bwolozin 0 ...
COMMENT This is a very interesting finding that suggests a direct link between cholesterol metabolism and Alzheimer's disease. bwolozin 0 ...
COMMENT Transcriptional activation by APP has become an increasingly current subject and provides important insights into the function of APP. This paper provides a novel set of proteins interacting with APP, and validates the increasing number of papers ...
COMMENT Developing adequate cell culture models of synuclein aggregation has proved challenging, and this paper makes a significant step forward. It is curious that the process is so slow, given that the cells divide and likely don't exist in the same state ...
COMMENT Proteasomal inhibition is thought to contribute to the pathophysiology of Parkinson's disease. The observations that proteasomal inhibition appears to recapitulate Parkinson's disease in a rat represents a potentially important advance for the ...
COMMENT Much work has been done on the structure of aggregated alpha-synuclein, but this is one of the first papers to examine the structure of protofibrillar alpha-synuclein associated with membranes. This is important because prior studies suggest that membrane ...
COMMENT This represents a potentially important advancement because quantitating plaque levels in vivo would provide an important new tool for clinical studies. bwolozin 0 ...
COMMENT Until now, Parkin has been the principal ligase implicated in neurodegenerative processes. This current paper focuses attention on another ligase that participates in the cellular response to protein aggregates. bwolozin 0 ...
COMMENT Previous studies by Checler suggested that A β could be produced by cells lacking PS1 and PS2. This current paper provides support for this surprising result, and identifies the specific compartment in which the A β species is produced, which could help ...
COMMENT Understanding the membrane localization of Memapsin 2 (BACE 1) could be very important for understanding the factors that control its activity. This paper provides an interesting analysis of factors controling the endocytosis of Memapsin 2. bwolozin 0 ...
COMMENT This is an interesting paper that describes a growing body of work with potentially significant clinical impact. Winkler and colleagues, who hail from the laboratory of Mathias Jucker, have investigated a transgenic APP mouse that exhibits a large amount ...
COMMENT This implicates PS2 in other mechanisms of neurodegeneration. bwolozin 0 ...
COMMENT Little is known about the biology of synuclein aggregation. bwolozin 0 ...
COMMENT Obiously important. bwolozin 0 ...
