Benjamin Wolozin on Distinctive neuropathology revealed by alpha-synuclein antibodies in hereditary parkinsonism and dementia linked to chromosome 4p.
COMMENT This suggests a new familial gene for Parkinson's disease. 0 bwolozin
216 RESULTS
COMMENT This suggests a new familial gene for Parkinson's disease. 0 bwolozin
COMMENT Important new information on AD. 0 bwolozin
COMMENT Cholinergic dysfunction appears to be more prominent in Dementia with Lewy bodies. Hence, use of acetylcholinesterase inhibitors, such as Rivastigmine, might be very useful for these patients. 0 bwolozin
COMMENT Estrogen is thought to be neuroprotective and this report suggests a possible mechanism. 0 bwolozin
COMMENT Important animal model of AD. 0 bwolozin
COMMENT Increasing data implicates iron as one of the toxins that predisposes to Parkinson's disease. This is particularly important because iron stimulates synuclein aggregation (Ostrerova, J. Neuroscience, 2000). This study provides a closer link between i
COMMENT Increasing evidence suggests that elements of the cholesterol pathway regulate Abeta production. This increases the importance of understanding cholesterol metabolism and trafficking in the brain. The discovery of disease related changes in cholesterol me
COMMENT Genes causing AD are clearly important. 0 bwolozin
COMMENT Important animal model of AD. 0 bwolozin
COMMENT Potential therapeutic approach in AD. Comes on the heals of Bush’s work showing that another antibiotic reduces plaque formation (through a chelation mechanism). 0 bwolozin
COMMENT This is important because it complements a recent report suggesting that caffeine is beneficial in PD. Both caffeine and nicotine elevate cAMP, so this report strengthens a putative link between cAMP and neuroprotection in PD. 0 bwolozin
COMMENT Novel mechanism for regulating APP processing. 0 bwolozin
COMMENT Important information on how Abeta is eliminated. 0 bwolozin
COMMENT Important clarification in an ongoing debate. 0 bwolozin
COMMENT There has been a longstanding debate about the role of apoptosis in AD. This paper provides some new details on this debate by identifying which pro-apoptotic proteins are elevated in AD. The selective elevation of particular proteins provides important c