206 RESULTS
COMMENT The paper by the Klann group presents an elegant study that highlights the importance of translational control at the synapse in the pathophysiology of Amyloidβ, and perhaps, neurodegeneration generally. When Aβ causes synaptic toxicity, it necessarily ...
COMMENT My memory of Larry is at a conference in Sweden. He gave a 20-minute talk that had about 230 slides. No joke. He had the slides set to advance automatically and talked continually, stream-of-consciousness style, with the slides changing about every five ...
COMMENT This manuscript presents some novel effects of oligomeric Aβ on neuronal biology. Mohamed et al. show that Aβ inhibits isoprenylation, and suggest that it does so by impairing cholesterol metabolism and SREBP-2 cleavage. The observations presented in the ...
COMMENT The "two-hit" hypothesis is consistent with the involvement of TDP-43 in stress granule biology. RNA binding proteins, such as TDP-43, have an inherent tendency to form cytoplasmic aggregates upon exposure to a stress. This work is discussed in ...
COMMENT The manuscript by Zhenyu Yue’s group presents a comprehensive analysis of the interaction of LRRK2 with 14-3-3 proteins, and adds to a growing body of literature suggesting that 14-3-3 proteins regulate LRRK2 function. The first report by Nichols and ...
COMMENT This is a very interesting study by Cynthia Kenyon's team. Their work in nematodes convincingly provides clear demonstration of a role for progranulin in phagocytosis, and confirms it by abrogation of the effect of progranulin deletion by deletion of ...
COMMENT The report by Esther Landhuis and Gabrielle Strobel reflects the inherent intellectual and financial turbulence that evolves when advancing technology interfaces with the patent system and commercial system. First, let’s examine the patent issues. It is ...
COMMENT The pathologies occurring in Alzheimer disease (AD) are curious because of their overlap with other disorders. Although accumulation of Aβ is most commonly associated with AD, neuritic plaques are also observed in Parkinson dementia, diffuse Lewy body ...
COMMENT LRRK2 R1441C Mice Recapitulate PD Motor Deficits The recent article by C.J. Li’s group reports on the first transgenic LRRK2 mouse model. The LRRK2 mouse uses a BAC system to express WT or R1441C LRRK2, which is a mutation in the GTPase domain of LRRK2. ...
COMMENT The picture posted above is basically how I remember things. I started in Peter's laboratory in the Department of Pathology at Einstein in 1984. At that time, from the student's perspective, there was a trio of heroes—Peter Davies, Robert Terry, ...
COMMENT The study by Cramer et al. follows in a long series of epidemiological reports studying the effects of statins on the incidence of Alzheimer disease. Most of the studies observe lower incidence of Alzheimer disease among statin users, although a small ...
COMMENT The results of the LEADe study provide clear evidence that atorvastatin does not delay the progression of Alzheimer disease. This result contrasts with a previous, preliminary study on atorvastatin by Sparks and colleagues, and it is disappointing [1]. ...
COMMENT Statins have been shown to be beneficial in preventing many different diseases in addition to cardiovascular disease, from osteoporosis to prostate cancer. Whether statins might be beneficial for those at risk of Alzheimer disease or suffering from the ...
COMMENT I would like to point out an elegant paper from the laboratory of Kumar Sambamurti that adds to this growing body of work examining isoprenylation and Aβ. Zhou and colleagues have published an article in FASEB Journal showing that geranylgeranyl ...
COMMENT Statins on the Brain This paper by Gary Landreth’s group casts important new light on the regulation of APP processing by statins and the actions of statins on small GTPases. Previous data demonstrate that statins inhibit APP processing. The mechanism is ...
