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Michael Wolfe on Nicastrin—A DAPper Role in γ-Secretase

COMMENT This is an excellent study from the lab of Gang Yu, the original discoverer of nicastrin as a presenilin partner needed for γ-secretase activity when he was with Peter St. George-Hyslop in Toronto. In his new lab at UT Southwestern, Yu has nailed down an ...

Michael Wolfe on No Toxicity in Tau’s Tangles?

COMMENT I found this paper fascinating and very intriguing, but could not determine whether the effects attributed to lowered tau levels (from the otherwise very high levels) are instead due to a neuroprotective effect of the drug used to control tau expression. ...

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