46 RESULTS
COMMENT Further evidence for the heterogeneity of protein aggregates, and a reminder that each transgenic model may have specific pathologic characteristics that should be considered when selecting a model for experimental purposes. lwalker 0 ...
COMMENT The developing brain is particularly sensitive to environmental insults, including infection, radiation, and toxins. Because the brain is still growing, differentiating, and establishing connections at this time, such hazards can influence brain structure ...
COMMENT This is a nice overview of an in-vitro approach to studying the relationship between structural variation of amyloidogenic proteins at the molecular level and resulting supramolecular aggregates ('spherulites'). lwalker 0 ...
COMMENT This is an important cautionary tale; if authors are disinclined to provide a current and comprehensive context for their work, reviewers and editors should compel them to do so. lwalker 0 ...
COMMENT The protean and itinerant nature of phagocytes has compelled researchers to devise increasingly ingenious experiments to establish their role in brain disorders, as exemplified nicely by the studies of Mildner et al. and Ajami et al. These researchers ...
COMMENT Disclosure: As an Alzforum advisor, I can't be entirely objective on this topic. However, it is impossible to deny the growing impact of web-based information-sharing on scientific communication. One hurdle for research websites will be standing out ...
COMMENT This is a nice review of the state of the art in applying viral vectors to treat Parkinson disease. Kirik and Bjorklund also have been involved in interesting work on modeling PD via focal expression of α-synuclein using viral vectors (e.g., Eslamboli et ...
COMMENT An edifying review of the parallels between two important 20th century discoveries- that DNA is the molecule that encodes hereditary information, and that a protein is the infective agent in transmissible spongiform encephalopathies. Opposition to these ...
COMMENT It appears likely that the abnormal conformation and assembly of specific proteins underlies a surprising variety of degenerative diseases of the brain and other organs. How proteins such as Ab cause neurodegeneration in Alzheimer's disease is still ...
COMMENT The origin, function, and sometimes even the existence of macrophages in the brain have been vigorously debated over the past century (see, for example, the historical overview by Peters, Palay, and Webster in The Fine Structure of the Nervous System, ...
COMMENT A recurring theme in the pathogenesis of diverse degenerative disorders is the accumulation of certain proteins in cells and tissues. Although many details remain to be ironed out, the pathogenic importance of cerebral Aβ accumulation in Alzheimer disease ...
COMMENT Alzheimer's disease is diagnosed definitively by the presence of amyloid and tau pathology in the context of dementia. Because plaques and tangles (the canonical AD lesions) can be detected with certainty only by histological analysis, a method of ...
COMMENT In search of the “β Bang” The evidence strongly favors a crucial role of the peptide Aβ in the pathogenesis of Alzheimer’s disease (AD). In vitro studies have nicely illuminated the mechanics of polymerization and fibrillization of Aβ and other ...
COMMENT The cyclin dependent kinases (CDKs) constitute a family of enzymes that regulates a variety of cellular functions. The importance of CDKs in cell cycle control has made these kinases attractive targets for the treatment of cancer (Sausville EA, Curr Med ...
COMMENT Neurofibrillary tangles consist of tau protein that has forsaken its role as a stabilizer of microtubules to polymerize into abnormal fibrils within neurons. Preclinical and clinical evidence leaves little doubt that abnormal tau polymerization is ...
