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Lary Walker on Widely Used Tau Seeding Assay Challenged

COMMENT Having speed-read the tau controversy, I would conclude that the findings of the Mandelkow group are reasonable within the context of their experimental conditions. The problem is one of comparing apples and oranges, as pointed out by Diamond et al. The D

Lary Walker on Like Prions, Tau Strains Are True to Form

COMMENT These thorough and elegant studies are the strongest evidence yet that seeds of tau protein behave like prions. They compellingly reinforce the prion concept as one of the most important pathogenic principles of our time. But since a prion is defined as a

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