60 RESULTS
COMMENT In this intriguing retrospective analysis of two large, independent databases, Zhao and colleagues report that the risk of spontaneous intracerebral hemorrhage (ICH) was significantly increased in recipients of red-blood-cell transfusions from donors who
COMMENT The research atmosphere in Don's lab was inspiring, enlightening, and enjoyable. When making the daily rounds, his standard opening query was “Any breakthroughs?” We quickly learned to anticipate this direct, but loaded, question, and as a result we
COMMENT Extracellular vesicles (EVs) have emerged in recent years as important vehicles of intercellular communication in many domains of biology. In the brain, EVs are produced by neurons and non-neuronal cells; their intercellular transfer can support homeostas
COMMENT This intriguing research from the Vorberg lab makes a strong case for the potential involvement of endogenous retroviruses (ERVs) in the spread of proteopathic seeds. The integration of work on yeast prions with mammalian cell culture models is a nice exa
COMMENT The ability of aggregation-prone proteins to adopt different structural and functional conformations (referred to as proteopathic strains) could help to explain the stage-like progression of several neurodegenerative diseases. There is circumstantial evid
COMMENT Although a prominent role of aberrant Aβ in the pathogenesis of Alzheimer's disease (AD) is no longer in reasonable doubt, how the structure of Aβ assemblies is linked to disease remains uncertain. Soluble, low-molecular weight assemblies of Aβ are d
COMMENT Jucker et al., 1994; comment on Baglietto-Vargas et al., 2021). Such astrocytic inclusions occur mainly
COMMENT Xiaohang Li, Dietmar Thal, and their colleagues nicely demonstrate that the pathobiology of aggregating Aβ is an evolving process, changing as Alzheimer's disease progresses in different parts of the brain. Using an exogenous seeding paradigm, they f
COMMENT An interesting historical view of the mechanisms underlying the prion-like formation and proliferation of multimeric protein assemblies such as amyloids. Be sure to view the supplemental video of Penrose machines. 0 lwalker
COMMENT This impressive new research from the Cambridge group supports previous NMR findings of Tycko and coworkers (Lu et al., 2013; Qiang et al., 2017) of a predominant Aβ structure in a particular AD brain. Using amyloid-binding dyes such as luminescent conjug
COMMENT This is an interesting and thoughtful modeling approach to understanding the temporal and spatial characteristics of tauopathy in the Alzheimeric brain. The findings indicate that both the replication and spreading of tau seeds contribute to the progressi
COMMENT A link between infectious pathogens and neurodegenerative disorders later in life is plausible but mechanistically enigmatic. It is fair to say that no single infectious agent is the cause of Alzheimer's disease (Walker, 2020), as has been proposed b
COMMENT Tauopathy is present in at least 25 neurodegenerative diseases (Spillantini and Goedert, 2013), and thus it is one of the most common proteopathies to afflict the nervous system. Postmortem investigations of tauopathies have documented the diversity of st
COMMENT As evidence grows for the importance of early intervention in Alzheimer's disease, an understanding of the initial pathogenic processes is essential. Michno and colleagues present iSILK as an auspicious method for following the development and compos
COMMENT Few scientists in the Alzheimer's field would disagree that we need an animal model that more faithfully manifests the disease as it occurs in humans. Genetically modified mice have been a boon to studies of cellular and molecular mechanisms, but the
