Inez Vincent on Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade.
COMMENT This is a beautiful study aimed at unraveling the connection between ApoE, a prominent risk factor for AD, and intracellular signaling and tau phosphorylation. Immunohistochemistry would have been very useful in the interpretation. Perhaps the authors are