57 RESULTS
COMMENT This describes an as-yet unknown and unexpected effect of lithium ions as inhibitors of γ-secretase, the intramembrane proteinase responsible for the cleavage of AβPP and Notch, among other targets. Thereby, lithium reduces the Aβ levels (40 and 42!) in ...
COMMENT The combination of mutant tau-P301L with the CDK5-activating cofactor p25 in brain of double-transgenic mice is proven here to increase phosphorylation of tau and its aggregation into filaments. This outcome is not totally unexpected, and confirms the ...
COMMENT This publication supports the notion that peri-vascular drainage is an essential and important pathway of clearing Aβ from the brain, as expressed in my recent comment on this site (See news, "Aβ, Shifty Drifter? Tissue Grafting Sheds Light on Plaque ...
COMMENT This publication has to be applauded for the lengthy and painstaking analysis of a two-way graft-host transplantation model, even and although grafting suspended embryonic cells into adult brain is not exactly a minor surgical procedure. The outcome, ...
COMMENT This study by L. Mucke and co-workers deserves credit for analyzing the "ApoE-isoform effect" in AD, a problem that is far from understood at the physiological level. The interesting results are situated on two levels:(i)synaptic deficit is ...
COMMENT Very good overview of current status of the problems of in vivo imaging and the prospects. fred.vanleuven 0 ...
COMMENT A very interesting study, characterizing the mouse model for Parkinson's disease and underlining its potential as directly related to new findings in human PD patients. fred.vanleuven 0 ...
COMMENT This is a laudable effort to generate and characterize a mouse model for an FTD-related pathology. By expressing the human tau[R406W] FTD-mutant using the CaMKII-promoter, the mice express the human mutant tau protein at a rather low level (20% of ...
COMMENT With regard to the above story by Gabrielle Strobel (very good, as always!), we want to comment on the following paragraph: "Recent work, in Lennart Mucke’s, Frank LaFerla’s, and Dominic Walsh’s labs, for example, hints [italics mine] at LTP changes ...
COMMENT Adding this type of fuel to a scientific debate is exciting. In the light of what is known (and not known) of APP and PS1, i.e. their normal function and their contribution to AD, this paper cannot but raise more questions. Too many cooks can ruin the ...
COMMENT The AD- A2M-connection is too weak to allow the statement as "involved in AD susceptibility" (abstract line 3). In addition, it must be stressed and remembered that A2M is indeed a pan-proteinase inhibitor, but NOT an acute-phase reactant in ...
COMMENT "Some excitement is in order following the Jackson et al study but commenter Rathan Bat should be reminded of some facts. Our experience in transgenic mice, and work by others in knockout mice, shows that extreme levels of GSK-3b are lethal, that is, ...
