Fred Van Leuven on Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein.
COMMENT Agreed and supported by our AAV-tau models; see reference below. 0 fred.vanleuven AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.