50 RESULTS
COMMENT The report by El Khoury and colleagues shows that recruitment of macrophage-like cells to the brains of Tg2576 mice via Ccr2 plays an important role in limiting AD-like pathology. This is a very interesting finding and extends the work of Stalder et al. ...
COMMENT This paper presents the interesting finding that immunization of the PDAPP mouse model of AD with the EFRH sequence of Aβ promotes neurogenesis. While many reports using the Aβ immunotherapy approach have focused on more classical AD-type pathological ...
COMMENT We appreciate the comments of Drs. Lemere and Solomon. I'd like to comment on a few of the issues they raised. Regarding cerebral microhemorrhage, it is correct that this adverse event has been observed in past "active" Aβ vaccines that ...
COMMENT The findings from Tony Wyss-Coray’s group suggest that that downregulation of neuronal TGF-βRII not only seems to “sensitize” neurons to injury in the context of Alzheimer pathology, but it also seems to amplify Alzheimer pathology by promoting ...
COMMENT In continuing their search for novel inhibitors of CD40 expression on macrophages/microglia, Wesemann and colleagues present data showing that SOCS-1 overexpression is able to mitigate IFN-gamma-induced CD40 expression in a macrophage cell line. It seems ...
