48 RESULTS
COMMENT I would like to respond to a reply made above by Doris Lambracht-Washington concerning the Th2 response issue raised by David Cribbs. Her reply was “Again, we would like to emphasize that an initial T cell response was observed by the isotype switching of ...
COMMENT The study by Lambracht-Washington and coworkers explores the possibility of using a DNA-based Aβ1-42 trimer vaccine to promote Th2-type, Aβ1-42-specific immune response in wild-type mice. As detailed above in comments from Michael Agadjanyan, this work ...
COMMENT This paper is thought provoking. A number of past studies have shown elevated circulating levels of pro-inflammatory cytokines, including TNFα, in AD patients. However, that body of literature is controversial due to failure to consistently reproduce such ...
COMMENT The paper by Lambert and colleagues is important and timely. For those of us in the field of neuroinflammation, their report adds fuel to the hypothesis that immune/inflammatory pathways are not epiphenomena, but are rather pathoetiologic in AD. ...
COMMENT While genetic susceptibility to familial and sporadic Alzheimer disease has become definitive, for decades the AD field has struggled with possible environmental initiators of, or contributors to AD pathoetiology. Suggestions have been made that heavy ...
COMMENT This interesting paper by Hawkes and McLaurin provides additional evidence that blood-borne macrophages are competent Aβ phagocytes. Their work further cements concepts from previous reports, which showed that blood-derived monocytes exist near cerebral ...
COMMENT The timely report by Hickman, Allison, and El Khoury presents an interesting interpretation of the interplay between microglia and cerebral amyloidosis. It has long been established that Tg2576 mice manifest microglial activation concomitant with Abeta ...
COMMENT This report is an interesting follow-on from a case report that showed evidence of Aβ plaque removal following immunization with the Elan/Wyeth AN1792 Aβ vaccine (Nicoll et al., 2003). Holmes and coworkers (2008) now extend the findings of the original ...
COMMENT The paper by Maier, Lemere, and colleagues (2008) provides an extension of previous findings by Wyss-Coray, Masliah, and coworkers (2002) showing that inhibiting the complement cascade in aged AD model mice (in the former case by knocking out C3; in the ...
COMMENT I wanted to thank Serge Rivest, Mathias Jucker, Tony Wyss-Coray, Joseph El Khoury, and Pritam Das for their helpful and thought-provoking comments, and to address some of their questions. I find it terribly interesting that the recent report by Richard, ...
COMMENT This interesting paper by Movsesyan and coworkers describes a novel DNA-based Aβ vaccine that relies on amino acids 1-11 of the peptide in combination with the synthetic T cell peptide, PADRE, and the Th2-promoting chemokine CCL22. The authors have nicely ...
COMMENT The paper by Bolmont and colleagues (2008) represents an elegant set of experiments designed to track microglia in a doubly-transgenic mouse model of AD. The authors crossed an Iba1-GFP transgenic (thereby labeling microglia green) with a co-injected APP ...
COMMENT The paper by Breunig et al. represents an elegant set of experiments, performed by a talented young investigator and aimed at dissecting the molecular mechanisms responsible for postnatal neurogenesis. Using tamoxofen-inducible Notch1 knockout mice and ...
COMMENT The report by El Khoury and colleagues shows that recruitment of macrophage-like cells to the brains of Tg2576 mice via Ccr2 plays an important role in limiting AD-like pathology. This is a very interesting finding and extends the work of Stalder et al. ...
COMMENT This paper presents the interesting finding that immunization of the PDAPP mouse model of AD with the EFRH sequence of Aβ promotes neurogenesis. While many reports using the Aβ immunotherapy approach have focused on more classical AD-type pathological ...
