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Terrence Town on Genomic analysis of reactive astrogliosis.

COMMENT This paper by Zamanian and colleagues represents a technical tour de force aimed at determining if heterogeneity exists in reactive astrocytes. To that end, they have provoked reactive astrogliosis either by 1) administering the bacterial endotoxin LPS ...

Terrence Town on ALS-TDI Scours Transcriptome, Targets CD40L

COMMENT Against the backdrop of sometimes disappointing results from genomewide association studies of the transcriptome (GWAS-T), the work by Lincecum and colleagues represents a triumph for this approach. The authors applied transcriptome analysis to the high ...

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