Terrence Town on Death by Glia?—Chemokine Receptor Nudges Neuron Loss in AD Mice
COMMENT other AD animal models. I’d like to comment on the present authors’ data showing that fractalkine
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Terrence Town on Amyloid β-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes.
COMMENT oligomeric preparations. I'd also like to comment on a point that the authors raised in their discussion
Terrence Town on DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model.
COMMENT I would like to respond to a reply made above by Doris Lambracht-Washington concerning the Th2 response issue raised by David Cribbs. Her reply was “Again, we would like to emphasize that an initial T cell response was observed by the isotype switching of
Terrence Town on DNA beta-amyloid(1-42) trimer immunization for Alzheimer disease in a wild-type mouse model.
COMMENT above in comments from Michael Agadjanyan, this work extends from pioneering studies that were
Terrence Town on Systemic inflammation and disease progression in Alzheimer disease.
COMMENT This paper is thought provoking. A number of past studies have shown elevated circulating levels of pro-inflammatory cytokines, including TNFα, in AD patients. However, that body of literature is controversial due to failure to consistently reproduce such
Terrence Town on Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
COMMENT like to comment on a statement made above by Julie Williams, that “our results suggest the possibility
Terrence Town on Herpes simplex virus type 1 DNA is located within Alzheimer's disease amyloid plaques.
COMMENT While genetic susceptibility to familial and sporadic Alzheimer disease has become definitive, for decades the AD field has struggled with possible environmental initiators of, or contributors to AD pathoetiology. Suggestions have been made that heavy met
Terrence Town on Selective targeting of perivascular macrophages for clearance of beta-amyloid in cerebral amyloid angiopathy.
COMMENT This interesting paper by Hawkes and McLaurin provides additional evidence that blood-borne macrophages are competent Aβ phagocytes. Their work further cements concepts from previous reports, which showed that blood-derived monocytes exist near cerebral v
Terrence Town on Why Good Microglia Turn Bad—A Matter of Timing?
COMMENT The timely report by Hickman, Allison, and El Khoury presents an interesting interpretation of the interplay between microglia and cerebral amyloidosis. It has long been established that Tg2576 mice manifest microglial activation concomitant with Abeta de
Terrence Town on AD Clinical Pipeline: Immunotherapy Woes, Dimebon Boons
COMMENT now been observed by us and by many others in AD mice. There are a few issues that I’d like to comment
Terrence Town on Complement: AD Friend or Foe? New Work Tips Balance to Former
COMMENT and Ly-6C (à la Geissmann and colleagues, 2003). I wanted to comment on a few points raised by Dave
Terrence Town on Macrophages Storm Blood-brain Barrier, Clear Plaques—or Do They?
COMMENT for their helpful and thought-provoking comments, and to address some of their questions. I find it
Terrence Town on Reducing AD-like pathology in 3xTg-AD mouse model by DNA epitope vaccine - a novel immunotherapeutic strategy.
COMMENT This interesting paper by Movsesyan and coworkers describes a novel DNA-based Aβ vaccine that relies on amino acids 1-11 of the peptide in combination with the synthetic T cell peptide, PADRE, and the Th2-promoting chemokine CCL22. The authors have nicely
Terrence Town on Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance.
COMMENT The paper by Bolmont and colleagues (2008) represents an elegant set of experiments designed to track microglia in a doubly-transgenic mouse model of AD. The authors crossed an Iba1-GFP transgenic (thereby labeling microglia green) with a co-injected APP/
Terrence Town on Postnatal Neurogenesis Tied in with Presenilins, Ephrin Signaling
COMMENT The paper by Breunig et al. represents an elegant set of experiments, performed by a talented young investigator and aimed at dissecting the molecular mechanisms responsible for postnatal neurogenesis. Using tamoxofen-inducible Notch1 knockout mice and in