David Teplow on Heads or Tails—What Makes an Amyloid Fibril?

COMMENT Serag et al. report the results of site-directed spin labeling (SDSL) studies of inter-residue distances in native and amyloid-associated forms of transthyretin (TTR). TTR is associated with a number of amyloidoses, including senile systemic amyloidosis ...

David Teplow on What Makes Amyloid Sticky?

COMMENT Among the most difficult problems for those interested in understanding the structural biology of amyloidoses are how to determine the complete three-dimensional structure of amyloid fibrils and to monitor the protein folding events leading to formation ...

David Teplow on Nomenclature Discussion

COMMENT There is nothing that upsets me faster than scientists using inappropriate and imprecise terminology and nomenclature. With respect to the Alzheimer's disease lexicon, the WHO and the International Nomenclature Committee on Amyloidosis have ALREADY ...

David Teplow on Toxic Protofibrillar Aβ

COMMENT In the news article cited above, two important facts need clarification. First, protofibrils are fibrillar. Second, the first demonstration that protofibrils were neurotoxic was published by my group, in collaboration with Drs. Hartley, Selkoe, and others ...

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