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Grace Stutzmann on Presenilin Loss of Function—Plan B for AD?

COMMENT Distilling the general comments and feedback from colleagues, most agree (as do I) that this new perspective is needed and appreciated, and does an amicable job of reconciling the unsettled role of β amyloid with presenilin loss of function. Taking a step ...

Grace Stutzmann on Presenilins Open Escape Hatch for ER Calcium

COMMENT This recent study by Tu et al. (2006) provides a much-needed advance toward understanding how presenilin (PS) mutations can alter ER Ca2+ signaling patterns. Cumulative data over the past several years have clearly shown that cells (both neurons and non ...

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