35 RESULTS
COMMENT In his PNAS Perspective, Vincent Marchesi, in characteristic fashion, provides us with substantial food for thought. Dr. Marchesi presents a cogently argued hypothesis that provides an alternative—or perhaps an addition—to the concept that Aβ oligomers ...
COMMENT Our study identifies a specific form of naturally produced human amyloid beta protein, namely stable low-n oligomers, as directly interrupting a key correlate of memory and learning in a living animal. Previous research by many scientists had linked Ab in ...
COMMENT Dave Holtzman nicely summarizes some of the principal findings of the presenters. In general, there was further experimental support for the conclusion that several different immunological approaches to clearing brain Aβ are effective in mouse models. ...
COMMENT I don't think this paper definitively rules IDE out as a LOAD gene. It simply says the authors could not find evidence for it in a case-control study of about 150 subjects with LOAD. It is not uncommon for different genetic methods to not confirm ...
COMMENT Reply by Dennis Selkoe Dear John: In response to your News and Views in the 8 April issue of Nature, I thought it would be helpful to indicate several points about your comments regarding the role of presenilins in APP processing with which my colleagues ...
