264 RESULTS
COMMENT The mutation is important to know the function of the molecule. Any articles like this paper are welcome to study presenilin. The Polish mutation is particularly interesting for its extremely high effect on amyloid production. mori 0 ...
COMMENT This group is undoubtedly one of the top research groups that provides the most concrete and firm evidence showing amyloid neurotoxicities. Their hypothesis is always challengeable and fascinating. mori 0 ...
COMMENT This paper may be important for the new lipid complex which is invovled in ApoE function of forming AD pathogenesis. mori 0 ...
COMMENT Astrocytic tau sturucture is recently popular because of its aberrant occurrence in pathological situations. This morphologically unique sturucture is interesting and may be a clue to understanding neuronal PHF or other tau inclusions. mori 0 ...
COMMENT It is not easy to understand the pathological function of Abeta42 in NPC. mori 0 ...
COMMENT Another paper showing that calcium ion is another central molecule for amyloid hypothesis. mori 0 ...
COMMENT The different effect of tacrine may be a clue to understanding the pathological role by ApoE. mori 0 ...
COMMENT The story is interesting. I wonder the reaction by Abeta1-40 beside Abeta1-42 because the former is secreted in a much higher amount. mori 0 ...
COMMENT The interaction of Abeta with apoE may be a hint for the treatment of AD because it is the possible regulation step to clear deposition of Abeta mori 0 ...
COMMENT Unquestionably this is a core paper for AD study. mori 0 ...
COMMENT It is a hot topic how apoptosis is involved in AD pathogenesis. This study shows some possible relationship although it is not enough. mori 0 ...
COMMENT It is useful to examine aggregation content by spectrometry to get the quantitative view. mori 0 ...
COMMENT This study is extremely important to show some basic property of presenilin-1. It is a remarkable point that the levels of Abeta 1-42/43 and A beta 1-40 peptides between PS1(+/-) and control mice are indistinguishable. mori 0 ...
COMMENT PS-1 is claimed to play a role in neuronal differentiation. It may explain some of disoprders seen in PS-1 knock-out mice. mori 0 ...
COMMENT Information should accumulate on evidence in vivo and in vitro study on amyloid fibril aggregation and formation. They must contribute understanding for the basic etiology of the pathology of AD. mori 0 ...
