Hiroshi Mori on Specific regional transcription of apolipoprotein E in human brain neurons.
COMMENT This result suggests that apoE expressed in neuron is the crucial factor to determine the specific pattern of pathogenesis. 0 mori
264 RESULTS
COMMENT This result suggests that apoE expressed in neuron is the crucial factor to determine the specific pattern of pathogenesis. 0 mori
COMMENT As the association between TFC2 and AD is significant, metal-related metabolic abnormality is an interesting factor. 0 mori
COMMENT D-amino acyl analogue peptide acid (PPI-433) may be able to be a therapeutic reagent. Such a trial is useful and welcome. 0 mori
COMMENT Association of upregulated C1q with amyloid plaque in Tg mice is worth emphasizing because it has been established to be in AD patient. Thus immunoresponse such as complement must play an important role in amyloid burden. 0 mori
COMMENT Anti-inflammatory drugs beside anti-oxicidant or steroid reagents are interesting because they are potent drugs to cure AD patients. This comes from clinical demand and from drug developer. The basic studies is requested to do more. 0 mori
COMMENT ELISA and its related monoclonal antibodies were used to analyze cerebral amyloid. Their evidence is so clear and worth referring. 0 mori
COMMENT The study with GFA promoter could provide some important information on apoE function. 0 mori
COMMENT This clearly denies the association of a gene near BCHE with AD. 0 mori
COMMENT This is one of papers that shows clearly the difference between two presenilins and their functions. 0 mori
COMMENT This is a unique research to understand the etiologies of AD and its related disorders. To study the molecular mechanism, we should learn the knowledge in a single neuron because there are heterologous populations of degenerating neurons even in a AD brai
COMMENT It is important to understand amyloid production as it relates to presenilin function and apolipoprotein E. The current hypothesis to emphasize Abeta1-42(43) is not enough and should be examined more using in vivo materials such as brain tissues. 0 mori
COMMENT Physicochemical information on amyloid peptide could be applied to disease indication as well as to basic results. 0 mori
COMMENT This report is negative but it is important to know the conclude derived from more than 100 cases that no significant association of the ACT genotypes (AA, AT, and TT) with the severity of CAA. 0 mori
COMMENT Well documented, microglial scavenger receptors may be novel targets for therapeutic interventions in Alzheimer's disease. They show further explanation here. 0 mori
COMMENT This claims the effect of PS1 mutation on protein trafficking with two different co-transfections. It is an interesting suggestion that mutant forms of PSI cause elevated production of A beta(42) by a mechanism that is independent of a major disruption of