52 RESULTS
COMMENT Response by Vincent Marchesi to comments through 28 September 2005 Dr. Russo points out that if Aβ peptides or fragments of them remain within the lipid bilayer after their generation, Aβ42, with two additional hydrophobic residues, should be more stable ...
COMMENT The strength of this paper is the imaginative use of carefully crafted recombinant peptides to study a complicated process that is difficult to approach using conventional cell biological techniques. But one also has to keep in mind that no "native ...
COMMENT This paper is one of the most interesting contributions of the year, and may well be one of the most informative animal models of AD yet published. To fully appreciate it, readers should first read two prior papers from this same group in which they ...
COMMENT I can't say that I agree with Paul Coleman's evaluation of this work. The method of analysis is quite convoluted, and it is not at all clear what is causing the difference in fluorescence intensity at particular wave lengths. It is very unlikely ...
COMMENT I agree with Martin and Gouras that this paper deserves serious study since it is an ambitious attempt to explore whether cleavage of APP at different subcellular sites determines whether Abeta peptides are ultimately toxic to the neurons in which the are ...
COMMENT Using a modified gel electrophoresis system, these investigators describe a series of longer forms of amyloid-β peptides in both transfected cells and transgenic brain tissue. These peptides include some that are 45, 46, and 48 amino acids long, which ...
COMMENT I agree that this is a very impressive attempt to use the power of energy transfer techniques to study the effects of NSAIDs on the organization of the presenilin/γ-secretase complex. I am concerned that the fluorophores used to measure lifetimes could ...
COMMENT This work largely confirms the earlier conditional KO study by Saura et al., 2004. There is a dramatic reduction in cortical tissue and a massive hydrocephalic-like appearance in animals that lack both presenilins. I wonder how significant and relevant ...
COMMENT This is an interesting but still incomplete story. This work dates back several years, when the authors found an unexpected ability of the Aβ peptide to bind to the enzyme alcohol dehydrogenase (ADH). It appears that the binding is relatively specific ...
COMMENT There are many reasons for believing that Aβ peptides, in one form or another, are important factors in the pathogenesis of AD. Although some investigators are skeptical that these peptide are necessarily the most important factors leading to this disease ...
COMMENT These are interesting experiments, but I think we have to be careful about interpreting experimetal results like these too literally. To say that cleavages occur at one "side" of a membrane, or in the "middle", so to speak, give the ...
COMMENT I think this issue is worth exploring, but I am concerned that the ability of a GPI-BACE chimera to cleave APP may be too artificial a model to tell us much about how the authentic BACE behaves. GPI-linked peptides would be expected to partition in rafts ...
COMMENT I have to agree completely with the comments of Exley. The illustrations purporting to demonstrate senile plaques are not convincing. Antibody immunoreactivity seems greater in some sets of animal than others, but without actual measurements of copper ...
COMMENT Small, soluble aggregates of the Aβ1-42 peptide are now believed to be the toxic factor that is responsible for synaptic dysfunction and eventual neuronal degeneration in Alzheimer's disease. This work adds to this consensus by showing that soluble ...
COMMENT Amyloid peptide-induced behavioral deficits in transgenic models of Alzheimer's disease are tightly linked to depletion of calcium-dependent proteins in granule cells of the dentate gyrus. This work builds on earlier observations that described the ...
