52 RESULTS
COMMENT Dr. Nardelli may have heard of the infamous Willie Sutton, a notorious American bank robber. When caught by the police, he was asked why he robbed banks so often. He replied "because that's where the money is". Many of us focus on APP and A
COMMENT The function of APP is an important question with many possible answers, since, like so many other trans-membrane proteins of similar molecular design, APP is likely to influence many membrane-related functions that depend on the context in which it is st
COMMENT The Relevance of APP Mutations Like Rudy Tanzi, I am impressed by the story that mutations can tell. Yet I think lessons learned from the study of APP mutants may be just as instructive as those of the presenilins. Some APP mutants increase the generation
COMMENT This paper confirms recent studies that demonstrate a decrease in AMPA receptor activity as a consequence of exposure to Aβ peptides, but it is more than just confirmatory. The earlier studies employed exogenous Aβ at relatively high concentrations, exper
COMMENT This is a landmark paper on how Aβ peptides might induce synaptic depression by reducing the number of AMPA receptors at postsynaptic sites of hippocampal neurons. The authors propose that Aβ peptides, either generated endogenously from APP, or added exog
COMMENT Peter Davies was too modest to proclaim, as he did in his closing comment, that he would be happy
COMMENT To their credit, the authors have attempted to look for early changes in the TG 2576 mouse model, which are more likely to deal with pathogenesis than pathogenic consequences. Lesne et al. have identified an unusual, high molecular-weight component in the
COMMENT Vincent Marchesi: Summary and Impressions It is a measure of the maturity of the Alzheimer disease field that many of its most prominent investigators seem willing, at least provisionally, to consider an alternative interpretation to the Aβ hypothesis tha
COMMENT Vincent Marchesi: Summary and Impressions It is a measure of the maturity of the Alzheimer disease field that many of its most prominent investigators seem willing, at least provisionally, to consider an alternative interpretation to the Aβ hypothesis tha
COMMENT Reply by Vincent Marchesi to comment by Karen Ashe Based on her recent studies, Dr. Ashe states
COMMENT Reply by Vincent Marchesi to comment by Karen Ashe Based on her recent studies, Dr. Ashe states
COMMENT Dr. Holtzman is correct to point out that my views on the possible fate of cleaved Aβ peptides were heavily influenced by the finding of Kawarabayashi and coworkers, who showed that significant amounts of the Aβ42 peptides were found associated with lipid
COMMENT Dr. Holtzman is correct to point out that my views on the possible fate of cleaved Aβ peptides were heavily influenced by the finding of Kawarabayashi and coworkers, who showed that significant amounts of the Aβ42 peptides were found associated with lipid
COMMENT to AD prevention, but the comments of Morgan are equally noteworthy. He raises questions as to how
COMMENT Response by Vincent Marchesi to comments through 28 September 2005 Dr. Russo points out that if Aβ
