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Vincent Marchesi on APP Family: Clues to Function in Health and AD

COMMENT The function of APP is an important question with many possible answers, since, like so many other trans-membrane proteins of similar molecular design, APP is likely to influence many membrane-related functions that depend on the context in which it is ...

Vincent Marchesi on Presenilin Loss of Function—Plan B for AD?

COMMENT The Relevance of APP Mutations Like Rudy Tanzi, I am impressed by the story that mutations can tell. Yet I think lessons learned from the study of APP mutants may be just as instructive as those of the presenilins. Some APP mutants increase the generation ...

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