34 RESULTS
COMMENT This is the latest paper in a series of studies looking at the modifying effect of LR11/SorLA on APP processing. Despite some differences to the previous paper by Andersen and coworkers, this study clearly highlights that increases in LR11/SorLA expressio
COMMENT It is great to see the continuation of the work on sorLA. The authors previously found that this protein influences APP shedding and Aβ generation, both under overexpression and knockout conditions. Their new work sheds more light on the underlying molecu
COMMENT It has been known for a while that the ectodomain of type I membrane proteins needs to be proteolytically trimmed before the proteins can be further processed by γ-secretase. This led to the speculation that γ-secretase—and more specifically, the nicastri
COMMENT As mentioned above in the comment posted by Martin Citron (March 18, 2004), we have a paper in
