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Stefan Lichtenthaler on Nicastrin—A DAPper Role in γ-Secretase

COMMENT It has been known for a while that the ectodomain of type I membrane proteins needs to be proteolytically trimmed before the proteins can be further processed by γ-secretase. This led to the speculation that γ-secretase—and more specifically, the ...

Stefan Lichtenthaler on Follow the Leader to Higher BACE Levels

COMMENT As mentioned above in the comment posted by Martin Citron (March 18, 2004), we have a paper in EMBO Reports dealing with translational control of BACE1 expression (Lammich et al., 2004). Like Mauro et al. and De Pietri Tonelli et al., we also found that ...

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