20 RESULTS
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COMMENT Promising results regarding the positive effects of exercise on cognition even after the accrual of AD-like brain pathology in aged Tg2576 mice. 0 clemere
COMMENT Drs. Nikolic, Tan, and their colleagues present an interesting paper demonstrating the efficacy of transcutaneous (TC) immunization with Aβ1-42 peptide and cholera toxin (CT) adjuvant. Wild-type and PSAPP (APPsw/PSEN1dE9) mice were immunized weekly for 4
COMMENT The recent PNAS paper by Okura and colleagues provides interesting new data regarding a nonviral Aβ DNA vaccine. It is encouraging that testing with two of the three naked DNA plasmid vaccines (Aβ-Fc and IgL-Aβ) against Aβ1-42 significantly lowered cerebr
COMMENT This study presents an interesting immunotherapy approach using influenza virosomes to present Aβ1-16 antigens for immunization. It appears to be targeted at soluble, oligomeric Aβ. Follow-up experiments addressing several technical questions may help adv
COMMENT Recent exciting work from Beka Solomon’s group demonstrates proof-of-concept for a novel way to block β-secretase activity using active immunization in mice to generate antibodies directed against the β-secretase cleavage site of APP. In a paper by Arbel
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