Gary Landreth on Truth Will Out: Negative, Confirmatory, Orphan Data Find New Outlets
COMMENT comments on the F1000 site is a valuable feature of this forum. gel2 0 ApoE-directed therapeutics rapidly
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Gary Landreth on PTEN Makes Aβ Depressingly Toxic
COMMENT This is an interesting and thorough study, whose experimental outcomes are pretty clear. One question one could ask is why chronic treatment with the PTEN inhibitor is necessary to improve the behavioral outcomes. There is no change in pAKT in the chronic
Gary Landreth on Proposed 2016 Budget Boosts Alzheimer’s Funding By 60 Percent
COMMENT The additional funding for AD research is a very welcome, but long overdue, development for those of us in the research community. The new funding has generated considerable excitement over the prospect of deploying new tools and understanding to dissect
Gary Landreth on New Therapeutic Idol? Silencing Ligase Prevents Aβ Deposition in Mice
COMMENT This is a compelling study from the Tontonoz lab demonstrating the role of LDLR in amyloid pathogenesis in a mouse model of AD. This work follows directly from their discovery that Idol acts to promote the proteolytic degradation of LDLR through its abili
Gary Landreth on Statins Boost Growth Factors in Mouse Brain, Improve Memory
COMMENT This recent publication by Roy et al. reports a novel, non-canonical action of statins in the brain, whereby they stimulate the nuclear receptor PPARα. There has been considerable controversy over the pleiotrophic actions of the statins, in particular as
Gary Landreth on Cytokine Takes Aβ Off the Menu for Microglia
COMMENT There is considerable confusion over the roles of neuroinflammation in animal models of Alzheimer’s disease and other neurodegenerative disorders. The complementary studies of Chakrabarty et al. and Guillot-Sestier et al. have shed new light, but not nece
Gary Landreth on Scanning ultrasound removes amyloid-β and restores memory in an Alzheimer's disease mouse model.
COMMENT This is an interesting and provocative study. There have been several related studies that have generated some interest, but this work has been at the margins of most people’s expertise and the technical aspects of the ultrasound treatment are hard for a
Gary Landreth on Effects of the absence of apolipoprotein e on lipoproteins, neurocognitive function, and retinal function.
COMMENT The recent report by Mak et al. is a thorough examination of an individual lacking ApoE. This case report is remarkable for its examination of neurological function and cognition, which appears entirely normal. The dyslipidemia observed in this individual
Gary Landreth on Has ApoE’s Time Come as a Therapeutic Target?
COMMENT therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models. Comment on "ApoE-directed
Gary Landreth on Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.
COMMENT The new work from Kim Green’s lab is remarkable and provides several important insights into microglial biology. The most dramatic finding from this study is the discovery that virtually all adult microglia are entirely reliant upon CSF1R signaling for th
Gary Landreth on Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.
COMMENT In the last decade, there has been a fundamental reevaluation of the origins and biology of microglia. Recent work has provided substantial new understanding about the critical roles these cells play in central nervous system disease and injury. In the pa
Gary Landreth on Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice.
COMMENT amyloid clearance and improved behavior in another AD model. 0 gel2 Comment on "ApoE-directed
Gary Landreth on Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology.
COMMENT The recent paper by Rivest and colleagues reports that a modified form of the Toll-like receptor 4 ligand monophosphoryl lipid A (MPL) elicits improvement in cognitive ability and reduction in plaque burden in APP/ΔE9PS1 mice. This study is of particular
Gary Landreth on ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.
COMMENT Reply to comment by Jian-Ping Guo, P.L. McGeer, and Claudia Schwab We communicated the results of
Gary Landreth on Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.
COMMENT In this paper, Terwel et al. show that microglial uptake of fibrillar Aβ is reliant upon ApoE. They nicely show that this effect relies upon astrocytic liver X receptors (LXRs), consistent with the idea that LXR agonists act to elevate ApoE-containing HDL