Edward Koo on Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice.
COMMENT Intersting report of sex difference in amyloid pathology in transgeni mice. Relevance to estrogen effect in AD? 0 edkoo
98 RESULTS
COMMENT Intersting report of sex difference in amyloid pathology in transgeni mice. Relevance to estrogen effect in AD? 0 edkoo
COMMENT In vivo evidence that abeta is physiologically cleared in brain. 0 edkoo
COMMENT I don't think this study argues for distinct proteolytic activities. One cannot saturate g-secretase activity by over-expressing APP. 0 edkoo
COMMENT Interesting study. A bit surprising since glu11 cleaved Ab is not that abundant in vitro or in vivo. Or, maybe we just haven't looked at the glu11 enough? 0 edkoo
COMMENT Another way to tell aging from pathology (ad and other neurodegenerative conditions?) 0 edkoo
COMMENT Even for Huntington's disease, it's a "use-it-or-lose-it" situation. 0 edkoo
COMMENT Timely review of a somewhat forgotten animal model. 0 edkoo
COMMENT Very interesting knock-in transgenic mice models where neither APP nor PS were overexpressed. 0 edkoo
COMMENT Nice study, but confirmatory nonetheless. 0 edkoo
COMMENT Nice study to define differences in amyloid biochemistry in different transgenic mice vs. humans 0 edkoo
COMMENT This result is consistent with other studies that APP is upregulated in development, but why? Maybe this is related the proposed signaling function of APP? 0 edkoo
COMMENT Interesting data but more APP binding proteins. What are they all doing? 0 edkoo
COMMENT Interesting approach. But the dating can be mislead by more turnover of plaques than tangles. 0 edkoo
COMMENT What does AD type pathology mean since the patients can be normal? Do we need better preclinical tests? 0 edkoo
COMMENT Results from this epidemiological study are unexpected. Based on accumulating experimental data, one would have predicted the opposite outcome. 0 edkoo