Edward Koo on Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation.
COMMENT More evidence that the +1 mutations causes cell dysfunction. 0 edkoo
98 RESULTS
COMMENT More evidence that the +1 mutations causes cell dysfunction. 0 edkoo
COMMENT Based on previous studies on brain trauma, these results are not surprising. What is surprising is that if a human specific abeta antibody is used, then it should not pick up rodent abeta as these are not transgenic animals. 0 edkoo
COMMENT Curious why synuclein seems to be associated with some (non-lewy body) neurodegenerative disorders but not others. I would be interested to see if the same is seen in the british and danish bri-associated dementias. 0 edkoo
COMMENT Interesting commentary. 0 edkoo
COMMENT Lovely study to show that under the right circumstances, overexpression of neither ps1 mutation nor app is required to generate amyloid deposition in brains of transgenic mice. The usual massive overexpression of app required to induce amyloid deposition
COMMENT Several labs have all reported this cleavage event:, eg. Christian Haass and Yasuo Ihara. But what does this imply mean for g-secretase at 40 and 42? Are they recleaved or is this event co-incidental to ab generation? 0 edkoo
COMMENT First good evidence that the in vitro effects of muscarinic stimulation can be seen physiologically. 0 edkoo
COMMENT Controversial approach to AD treatment. Must await new trial data. Current review if from originator of technique. 0 edkoo
COMMENT Another pathological marker for mci? 0 edkoo
COMMENT THIS STUDY SUGGESTS THAT MAYBE THE INFLAMMATORY CHANGES IN AD MAYBE SPECIFIC TO NEURITIC PLAQUES. 0 edkoo
COMMENT This is a nice, though small, study. I suspect this is the beginning of a series of human studies showing that statins lower abeta, as has been shown in transgenic mice. Will this is effective AD treatment or prevention? 0 edkoo
COMMENT Another interesting issue from Neurobiology of Aging with a series of commentaries. 0 edkoo
COMMENT More evidence against the stress response role of ps. Curious that the ps knock in mice show very little deficits. 0 edkoo
COMMENT Some negative data regarding the role of cdk5/p35 in AD. see LH Tsai, Nature, 1999. 0 edkoo
COMMENT Another function for ps, also related to protein degradation but not like app or notch clevage. 0 edkoo