98 RESULTS
COMMENT First detailed characterization of the Aβ immunoreactive deposits in these anti-NGF mice. A lot of questions were raised since the initial publication in PNAS a couple of years ago. In this paper, the changes are impressive but these are really not tradit
COMMENT A potential explanation for selective vulnerability of motoneurons in ALS. Whether the motoneurons cultured from embryos can be extended to other neurons in the body is unclear. The curious sparing of oculomotor neurons remains a big mystery to me. 0 edko
COMMENT Convincing evidence that ADAM10 is requred for notch S2 cleavage but unclear how it may be involved in APP alpha secretase cleavage. Ultimately, alpha-secretase may indeed be a collection of protease rather than one, could gamma be the same?? 0 edkoo
COMMENT Many of Sidney Wolfe's accusations of ADAPT are unfounded although I appreciate their caution that giving these drugs to elderly individuals can be potentially dangerous. I will focus only on those aspects that concern our work as I think our results
COMMENT A nice and different way to look at the phenomenon of "synaptosis" first reported by the Cole lab. 0 edkoo
COMMENT The γ-secretase complex gains more integral members necessary for function. Similar results reported at Int'l AD meeting in Sweden this summer but Haass lab wins this sprint! 0 edkoo
COMMENT While not AD or neurodegeneration, this is a very interesting finding as there are no good models of dystonia. This may be one such model. 0 edkoo
COMMENT Apparent confirmation of the peripheral sink idea from David Holtzman and Steve Paul? 0 edkoo
COMMENT Interesting localization of abeta at sites of macular degeneration. The Aβ lies outside the retinal pigment epithelium, so I guess this is technically outside the nervous system (?) The authors argue that the abeta may activate local inflammatory response
COMMENT Interesting study to link rotenone's inhibition of complex I with PD pathology, i.e. alpha-synuclein and ubiquitin abnormalities and cell death. 0 edkoo
COMMENT Negative study but does lend support the idea that not all tauopathies are the same. 0 edkoo
COMMENT Further work on insulysin (insulin degrading enzyme) in proteolysis of amyloid peptide. 0 edkoo
COMMENT If this works in humans, it will be great for antemortem quantitation of amyloid load. 0 edkoo
COMMENT Three studies on the app-jip interaction. What does this do? 0 edkoo
COMMENT "Surprising in vivo evidence that cdk5 may not phosphorylate tau in brain." 0 edkoo
