29 RESULTS
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COMMENT The trial of IVIg (Gammagard) for treating AD patients was done with the aim of augmenting their relatively low level of anti-Aβ antibodies, thereby enhancing the clearance of Aβ. We wonder if, instead, the beneficial effect of IVIg might have been throug
COMMENT The similarity, or otherwise, of HIV-associated neurologic disease to dementia of the Alzheimer’s type (DAT) seems as vexed a topic as that of an ApoE-ε4 association (or not) with HIV dementia or HIV encephalitis. In this paper, Clifford et al. (1), like
COMMENT We would like to respond to a few points in the comments by Moir and Tanzi. They state that 1.
COMMENT What good news that microbes are becoming acceptable as possible agents in AD. Regarding the proposal of a generic mechanism, “not one based on any particular organism,” surely a prerequisite for the participation of a putative agent in AD, a disease of l
COMMENT We thank the commentators for their (mostly) positive views and hope that our results will
COMMENT It’s good to see yet another study showing that a genetic factor determines outcome of infection by a microbe—a concept all too rarely understood though indicating simply that infected might not mean affected, so that an infected individual might suffer s
COMMENT Another Herpes Virus-Alzheimer’s Disease Connection: Beclin Beckons This study not only strengthens the link between AD and autophagy by relating it to a reduced beclin 1 activity in the diseased brain. It also strengthens, indirectly, another link which
COMMENT In this innovative study, Miller and Federoff report new evidence intimately linking apolipoprotein E (ApoE) and herpes simplex virus type 1 (HSV1), which strengthens the case that the two factors together are important in Alzheimer disease (AD). The auth
COMMENT We would like to add to Brian Balin’s interesting comment that encephalitis and hippocampal damage
COMMENT Brian Balin has written his Challenge so impressively, in particular stressing the insidious (though sporadic) nature of stealth microorganisms, that there is little to add except a few hopefully apposite points. Apropos of the extraordinary resistance of
COMMENT Infants and young children are subjected to a battery of infectious agents, including human herpes virus 6, herpes simplex virus type 1 (HSV1), adenoviruses, respiratory syncytial virus, rhinoviruses and probably enteroviruses, and these, as well as overt
COMMENT commented on the support for a role of infectious agents in AD afforded by the intriguing similarities among
COMMENT It was good to read the report on the AIDS study presented at San Diego by Lynn Pulliam and colleagues, because her poster on this topic at the International AD conference in Philadelphia in July might not have been seen by many. However, it is worth ment
COMMENT I was sorry not to be able to participate in the forum on DNA repair on Monday, but I wonder if anybody was aware that we worked on that topic some years ago (published between about 1987 and 1993). It was on gamma-irradiation of lymphocytes, looking at
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