Costantino Iadecola, Laibaik Park on Do Perivascular Macrophages Mediate Aβ Pathology?
COMMENT We thank Drs. Nelson, Kisler, and Zlokovic for their positive comments on our paper. The role of
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COMMENT We thank Drs. Nelson, Kisler, and Zlokovic for their positive comments on our paper. The role of
COMMENT This paper by Auriel et al. addresses an important clinical problem. CAA with an inflammatory component is an aggressive and devastating disease, possibly autoimmune-based, but can be ameliorated by treatment with immunosuppression. Therefore, differentia
COMMENT This paper provides a comprehensive and quantitative assessment of the permeability of the blood-brain barrier in models of neurodegenerative diseases. Strengths of the assessment include the use of multiple mouse models of neurodegenerative diseases and
COMMENT The elegant paper by Takeda et al. demonstrates that crossing APP-overexpressing mice with leptin-deficient mice, a model of a metabolic syndrome including hyperglycemia, exacerbates the cognitive decline observed in APP mice (APP23). The effect was obser
COMMENT The authors investigated the vascular alterations occurring in a mouse model of Alzheimer disease (AD) using corrosion casts and scanning electron microscopy. They report that APP23 mice exhibit structural alterations in cerebral microvessels before full-
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