70 RESULTS
COMMENT In this paper, the expression "10cM resolution": is misleading because linkage disequilibrium only strethes for 0.5cM (at most). Thus, this assesses identity by descent at spaced patches throughout the genome. J.Hardy 0 ...
COMMENT A heroic and painstaking study… but we still don't really know what APP does. J.Hardy 0 ...
COMMENT Now proven almost beyond reasonable doubt: presenilin = gamma secretase. The three papers almost establish beyond reasonable doubt that presenilins are the long-sort after gamma secretases. The questions that remain include what are the other components ...
COMMENT "An interesting paper which shows yet another way of reducing plaque load... as a result of the transgenic work, there are now many hopeful avenues for the drug industry and academics to look for Alzheimer treatments." J.Hardy 0 ...
COMMENT An amazing technology used to show, once and for all, that plaques are dynamic structures. A great paper which subverts the huge literature seeking to correlate plaque numbers with clinical features. Pathology does not wait around to be counted!!!" J ...
COMMENT "An excellent paper, not only establishing BACE as b-secretase but also suggesting that knockout (or, by implication drug inhibition) may not have major adverse effects." J.Hardy 0 ...
COMMENT A fascinating paper which starts to move the study of inclusion body myositis on from phenomenology. J.Hardy 0 ...
COMMENT An interesting paper... it would be good to know, though, whether tau was "essential" to other forms of induced neurotoxicity. J.Hardy 0 ...
COMMENT "At last, a welcome attempt to try and deal with the problems of multiple testing in association studies." J.Hardy 0 ...
COMMENT A fascinating study which further emphasises the parallels between tau andsynuclein pathobiology: mutations in both genes lead to pathology, haplotypes at both genes predispose to sporadic disease, both pathologies occur 'downstream' in ...
COMMENT It will be interesting to see whether doppel antagonises this effect. J.Hardy 0 ...
COMMENT An extremely important paper which provides the experimental evidence that cholesterol lowering drugs may be beneficial to Alzheimer's disease..... while this paper does not use statins, the treatment implications are clear. From a basic science ...
COMMENT This is an interesting and thorough paper discussing the details of tau splicing regulation. However, it comes to the suprising, and probably erroneous conclusion that there is not a stem look structure at the exon 10 splice site, but rather, that the ...
COMMENT While the homology between these proteins and PS1 and PS2 is not great, their importance is that their occurrence suggests there may be many other regulated membrance cleavage pathways and detailed comparisons may also give mechanistic insights into the ...
COMMENT This is an exciting, if expensive method which allows real time visualisation of plaques J.Hardy 0 ...
