69 RESULTS
COMMENT Can we use SNP's and CHIP's to find genes which lead to complex diseases including late onset AD: this important paper illustrates it will be extraordinarily difficult or perhaps impossible. J.Hardy 0 ...
COMMENT Exciting data, which with animal data of Sparks and Refolo and colleagues, and clinical data from Wolozin and Jick and colleagues really puts cholesterol center stage in terms of APP metabolism. Is this the connection between ApoE and amyloid? J.Hardy 0 ...
COMMENT however, DS individuals without three copies of the APP locus do not appear to get AD (Ann Neurol. 1998 Mar;43(3):380-3) J.Hardy 0 ...
COMMENT Clearly of practical relevance to therapy. J.Hardy 0 ...
COMMENT The central role of alpha synuclein in both AD andin PD is well established.. it's function in the normal neuron remains mysterious: perhaps there are clues here. J.Hardy 0 ...
COMMENT The difficulty we have had proving a role for the polymorphisms in the APOE promoter in AD (and the general consensus seems to be that they have a role), illustrates the difficulty we will have in determining whether genetic variability at other non ...
COMMENT This, together with the equally unfortunately named, British dementia, are extremely informative "models" for AD. J.Hardy 0 ...
COMMENT A fascinating paper which raises the suggestion that the reason Africans appraently don't have as high an incidence of AD is because of their lower cholesterol intake. J.Hardy 0 ...
COMMENT Together these papers (Locatelli et al., Okamura et al., and Rockwood et al.) further the interesting link between cholesterol metabolism and AD J.Hardy 0 ...
