67 RESULTS
COMMENT With the completion of the HapMap and its commercialization by Illumina and Affymetrix, it should be possible for researchers to find susceptibility alleles which have an odds ratio of >2 for any disorder, including Alzheimer disease, over the next ...
COMMENT This paper is wrong, of course. J.Hardy 0 ...
COMMENT This an extremely interesting preliminary report. The editorial by Winblad and Blum is very careful in conveying both the excitement this data causes, and also the caution that needs to be exercised in its interpretation. Hock and his colleagues are to be ...
COMMENT Reply to comment by Rudy Tanzi. Phillipp Kahle's and Bart De Strooper's comments on the Titisee Conference capture the flavor of the discussion on IDE (and other genes), especially between Steve Younkin and me. Deciding which other genes ...
COMMENT An interesting and provocative paper. If the M232R mutation is pathogenic, then this suggests that DLB may be a alternative expression of prion disease. It is worth noting that Ghetti has published (in abstract form only) that other prion mutations have ...
COMMENT This is a very surprising finding which may suggest that the incidence of BSE-caused CJD is about twice what was thought... this is just over 100 people so far. J.Hardy 0 ...
COMMENT This is a fascinating problem. Why should a mutation on one haplotypic background be recessive, but on others be dominant? J.Hardy 0 ...
COMMENT A very interesting paper: I caution still, however, that a genetic role for UCH-L1 in Parkinson's is not yet established. J.Hardy 0 ...
COMMENT So much that has been important for the understanding of APP biology has come from C elegans (and Drosophila). This paper is probably going to have a long-term importance. J.Hardy 0 ...
COMMENT A great review of an increasingly interesting area. J.Hardy 0 ...
COMMENT The immunization story has really been a rollercoaster ride of excitement and then despair. This review discusses the work in a more sober light. It is too early to know whether this approach will work, but early L-dopa trials were generally a failure. J ...
COMMENT This, and the remarkable paper from from Francis and colleagues, mark real progress in the dissection of the gamma secretase complex... perhaps we are now close to knowing all it's components J.Hardy 0 aph-1 and pen-2 are required for Notch pathway ...
COMMENT In this paper, the expression "10cM resolution": is misleading because linkage disequilibrium only strethes for 0.5cM (at most). Thus, this assesses identity by descent at spaced patches throughout the genome. J.Hardy 0 ...
COMMENT A heroic and painstaking study… but we still don't really know what APP does. J.Hardy 0 ...
COMMENT Now proven almost beyond reasonable doubt: presenilin = gamma secretase. The three papers almost establish beyond reasonable doubt that presenilins are the long-sort after gamma secretases. The questions that remain include what are the other components ...
