41 RESULTS
COMMENT This is a fascinating example of what appears to be another "functional amyloid." In this, the function is more active and interesting because it is regulated by neuronal activity, rather than serving as a scaffold for melanin, or as a storage f
COMMENT Previous studies on small groups of patients have indicated that IVIg treatment may have therapeutic benefit for AD (Dodel et al., 2004; Relkin et al., 2008). This report by Fillit et al. appears to be the broadest test of the effectiveness of IVIg treatm
COMMENT This is certainly a fascinating observation that healthy young individuals have relatively high concentrations of these circulating antibodies and that their levels seem to decline with age and in AD. It is also important that immunization against Aβ caus
COMMENT Anti-amyloid immunotherapy remains one of the front-line strategies for the development of Alzheimer therapeutics. Both passive and active immunization are currently under active development for human clinical application. Antibodies that target the amino
COMMENT Alzheimer scientists have long known that amyloid plaques are not always associated with cognitive dysfunction. Indeed, some cognitively normal individuals have impressive numbers of insoluble amyloid plaques. Recent studies have shifted the focus to solu
COMMENT It is quite likely that amino-terminal deletions could also have an impact on the aggregation of Aβ. Christian Pike and Carl Cotman showed that amino-terminally truncated peptides aggregate faster than the corresponding full-length peptides. In addition,
COMMENT An interesting insight into the potential function of PrP(C). 0 cglabe
COMMENT Parallel, in-register β strand packing is turning out to be a common motif in amyloid fibrils of many diseases. This leads to the stacking of amino acid side chains of the same type as zippers runing up and down the β sheet. 0 cglabe
COMMENT More details about how polar and non polar zippers in parallel, in-register amyloids mediate sheet stacking interactions in fibril structures. 0 cglabe
COMMENT Amyloids assemble into nanoscale fibrils and oligomers, so nanomedicine may provide insights into their properties and novel strategies for their therapeutic modulation. 0 cglabe
COMMENT Prefibrillar amyloid oligomers are intrinsically toxic in rat brain regardless of their amino acid sequence. 0 cglabe
COMMENT Inhibitor of Htt misfolding and oligomerization reduces polyQ toxicity in vivo. 0 cglabe
COMMENT Soluble Abeta levels are elevated in AN-1792 vaccinated patients. 0 cglabe
COMMENT This paper is interesting because it describes some of the structural differences between Aβ fibrils and oligomers, and there is very little known about oligomer structure. The data indicate that while some regions are similarly disordered in fibrils and
COMMENT It is surprising and unanticipated that a mitochondrial matrix peptidase would play a role in degrading Aβ. It begs the question of how Aβ, which is normally considered to be a secreted protein, would be mislocalized to the mitochondria matrix. 0 cglabe
