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Samuel Gandy on SUMO-Wrestling with APP?

COMMENT Posttranslational modification of the cytoplasmic tail of APP has emerged as an important mechanism for controlling APP metabolism and Aβ generation. These phenomena can be divided into two basic cellular phenotypes: modifications that regulate the α- and ...

Samuel Gandy on Intracellular Aβ in Alzheimer's Disease

COMMENT The idea that intracellular Aβ injures neurons and causes dementia prior to the formation of extracellular deposits is not obviously reconcilable with other evidence indicating that "full-blown" structural pathology precedes dementia (Crystal H, ...

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