24 RESULTS
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COMMENT These two studies cover different aspects of oxidative stress. The Brewer group showed that wild-type mice as well as 3x transgenic mice developed oxidative changes that could be ameliorated with nicotinamide. The Ho group showed calcium-dependent changes ...
COMMENT This JAMA paper subjects a number of blood-based tests, thought to have diagnostic discrimination in initial publications, to meta-analysis, and found greatly reduced discrimination. Does this mean that current enthusiasm for AD biomarkers should be ...
COMMENT This study is timely in comparing two widely used platforms (ELISA and bead-based multiplex assays [X-MAP]) for measuring cerebrospinal fluid (CSF) analytes related to Alzheimer’s disease. The results support assays for CSF Aβ42 and total tau as being ...
COMMENT This is an excellently written and compelling review, which adds to the drumbeat of support for early intervention or prevention as the design for disease modifying clinical trials in AD. The review is appropriately amyloid-centric, because amyloid has ...
COMMENT The remarkably high incidence of ALS among the Chamorros of Guam in the mid-1940s, and the characterization of a related neurodegenerative disorder, Parkinson-dementia complex (PDC), have never been adequately explained. Patterns of disease within ...
COMMENT The JAMA commentary by Carol Brayne et al. carefully considers the issues surrounding routine screening for dementia by primary care practitioners (PCPs). Although enthusiasm has repeatedly been voiced for widespread screening for dementia in the elderly ...
COMMENT I find these results interesting. Since I'm not an expert in Ab aggregation, I cannot comment on the experimental results, other than to say that they are very preliminary. Unfortunately, the epidemiology on smoking and AD is not uniformly in favor ...
COMMENT The argument that A-beta alterations precede the onset of AD is reinforced by this interesting study of CSF A-beta levels in the oldest old. Decreased levels of A-beta 42 were found in nondemented oldest old subjects, and A-beta42 levels in the lower 50th ...
COMMENT The three papers examine the important issue of whether subtle changes in psychometric measures can provide predictors as early as 3-5 years before patients develop an "end point" such as mild dementia or mild cognitive impairment (MCI). Many ...
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