31 RESULTS
COMMENT In this paper, the authors conducted an interesting secondary analysis of CSF and longitudinal tau PET data from ADNI. CSF levels of GAP-43, a presynaptic protein important in neurodevelopment and in axonal regeneration, are increased in MCI and AD, and h
COMMENT Protein biomarkers for Parkinson’s disease and DLB have been sought extensively, with far fewer hits than in AD. Recent efforts using the O-link multiplex immune-PCR assay system for discovery have yielded interesting results. In a large, multicenter CSF
COMMENT The remarkable ability of seed amplification assays (SAA), such as RT-QuIC, to detect pathological α-synuclein in CSF has enabled many interesting clinical questions to be addressed, in particular, those related to early diagnosis of synuclein disorders.
COMMENT a variety of donors are to be studied. This comment has some parallels with mouse models. For example, the
COMMENT Steve Wagner, who passed away on March 12, 2022, after a sudden illness, is deeply mourned by friends and colleagues at UCSD, his academic home for the past decade, and by the many people whose lives he touched. Steve trained in biochemistry and cell biol
COMMENT I have greatly valued John’s enormous contributions in the field of molecular neuropathology relevant to Alzheimer’s and had the privilege of collaborating with him on several projects over the years. One of these areas was ALS-PDC of Guam, where John ana
COMMENT This is an extremely helpful initiative that will have a huge impact on iPSc research in relation to AD and other neurodegenerative disorders. There are many advantages to studying human neurons and glial cells as models for these disorders. Rodent models
COMMENT I am a paid consultant for Biogen, so will not comment directly on the FDA’s deliberation of
COMMENT The COVID-19 pandemic has had a tremendous impact on human subjects research in which I am involved. Our overarching policy is that we need to minimize risk for study participants and research staff. We also are cognizant of resource utilization, e.g., ke
COMMENT hypothesis. I am a site investigator in one of these Biogen trials, hence will only comment in general terms
COMMENT I have not seen the announcement, but my general comments relate to two questions: target and
COMMENT I read this paper with interest. There are many substrates besides VCAM1 that might be altered as a result of BACE-2 inhibition, with potentially unknown effects on the brain. The magnitude of alteration was clearly higher in the presence of TNF-α, which
COMMENT explained. As a general comment, for many biomarkers, initial performance through best fits to develop
COMMENT The study of NfL in autosomal-dominant AD (ADAD) provides exciting preliminary evidence supporting this as a progression marker. The effect size was much more impressive in symptomatic patients than in preclinical carriers, and it will be interesting to s
COMMENT Neurogranin appears to be an interesting and novel marker that appears to reflect post-synaptic damage. There are multiple proteolytically cleaved forms of neurogranin in CSF; this is reminiscent of tau, with which neurogranin correlates. It is possible t
