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Jürgen Götz on Mutant Tau Sharpens Wits of Young Mice

COMMENT This study of a beneficial effect of tau as shown by improved long-term potentiation, in the absence of tau hyperphosphorylation, demonstrates that tau mutations, such as P301L, are not per se causing cognitive decline. As this research group has in the ...

Jürgen Götz on Dangerous Liaisons—Tau and Aβ, Together at Last?

COMMENT The identification in this paper of a complex formation between Aβ and tau by Patrick McGeer’s group (Aβ and tau form soluble complexes that may promote self-aggregation of both into the insoluble forms observed in Alzheimer disease) by Western blotting, ...

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